Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Momordica dioica for Hepatoprotective, Antioxidant, and Antiinflammatory Activities

  • Shreedhara, C.S. (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences) ;
  • Vaidya, V.P. (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences)
  • Published : 2006.09.01
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Abstract

The alcoholic extract of Momordica dioica roots significantly reduced $CCl_4$ induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transminases (SGPT), and alkaline phosphatase (ALP)]. These results were comparable with sylimarin (1.25 mg/kg, p.o.). The alcoholic extract inhibited the formation of oxyten derived free radicals (ODFR) in vitro with $4000\;{\mu}g/ml$ ascorbic system. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) and the activity was comparable with ibuprofen(200 mg/kg, p.o.).

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References

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