Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Antiulcer Activity of Sida acuta Burm.

  • Published : 2006.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

The ethanol extract of Sida acuta Burm. (ALSA) whole plant was studied for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer, HCl-ethanol induced ulcer, and water immersion stress induced ulcer (WISIU) in rats. We found that ALSA at a dose of 300 mg/kg, (orally) markedly decrease the incidence of ulcers in the first two models. ALSA showed reduction in gastric volume, free acidity, and ulcer index (53.69%). It has not reduced the total acidity significantly and no significant change in pH. It also showed 55.14% gastro protective activity, wheres standard drug sucralfate showed 94.85%. WISIU showed protection index 24.4%, whereas standard drug omeprazole (OMEZ) showed protection index 100%.

Keywords

References

  1. Ahmad, Moghos, U., Husain, S.K., Ahmed, M., Osman, S.M., and Subbarao, R., Cyclopropenoid FA in seed oils of S. acuta and S. rhombifolia (Malvaceae). J. Am. Oil. Chem. Soc. 53, 698-699 (1976) https://doi.org/10.1007/BF02586341
  2. Alphine R.S. and Word J.W., Antihistaminic activity and ulceration. European J. Pharmacol. 6, 61-66 (1969) https://doi.org/10.1016/0014-2999(69)90066-1
  3. Chung, C.K. and Chih, Y.T., Studies on the Chemical constituents of the herb huanghuaren (Sida acuta Burro f.). J. Chinease Materia Medica 18, 681-682 (1993)
  4. Donald J. Ecobichon, The basis of toxicity testing, CRC Press, New York, pp. 43-49 (1997)
  5. Goel, R.K., Chakrabarti, A., and Sanyal, A.K., The effect of biological variables on the antiulcerogenic effect of vegetable plantain banana. Planta Medica 2, 85-88 (1985)
  6. Guntalika, A.A.L., Sootheeswaran, S., Balasubramaniam, S., Chandrasekara, A.I. and Syriani, H.T.B., Studies on medicinal plants of Srilanka, Part 3. Pharmacologically important alkaloids of some Sida species. Planta Medica 39, 66-72 (1980) https://doi.org/10.1055/s-2008-1074904
  7. Kholute, S,D., Munshi, S.R., Naik, S.D., and Jathar, V.S., Antifertility activity of indigenous plants Sida carpinifolia Linn.& Podocarpus brevifolius stapf in female rats, Indian J. Exp. Biol. 16, 696-698 (1978)
  8. Krishnamurthi, A. and Chada,Y.R. (eds.), Wealth of India, Publication and Information Directorate, CSIR, New Delhi. IX, pp. 322-326 (1972)
  9. Kirtikar, K.R. and Basu, B.D., 1995. Indian Medicinal Plants, International Book Distributors, Dehradun, India. pp. 308-309 (1995)
  10. Krishna Rao, R.V., Sathyanarayana., and Kameshwararao, B.V., Phytochemical investigation on the roots of Sida acuta growing in Waltair, Fitoterapia 55, 249-250 (1984)
  11. Kulkarni S.K., Handbook of Experimental pharmacology, Vallabh Prakashan, New Delhi, pp. 148-150 (1999)
  12. Kurma Rao and Mishra, S.H., Anti-inflammatory activity and hepatoprotective activities of Sida acuta, Indian Drugs 35, 92-97 (1998)
  13. Yang, L.L., Yen, K.Y., Yoshinobu, Kiso., and Hiroshi Hikino, Antihepatoxic actions of Formosan plant drugs, J. Ethnopharmacol. 19, 103-110 (1987) https://doi.org/10.1016/0378-8741(87)90142-5
  14. Nadkarni, K.M., Indian Materia Medica, Popular Prakasan, Mumbai, 1, 1134-1135 (1954)
  15. Otero-R, Nunez, V., Jimenenz, S.L., Fonnegra, R., Osorio, R.G., Garcia, M.E., and Diaz, A., Snakebites and the ethnobotany in the northwest region of Colombia. Part II: neutralization of lethal and enzymatic effects of Bothrops Otrox venom. J. Ethnopharmacol. 71, 501-511 (2000)
  16. Prakash, A., Varma, R.K., and Ghosl, S. Alkloidal constituents of Sida acuta, S.humile, S.rhombifolia and S.spinosa, Planta Medica 43, 384-388 (1981) https://doi.org/10.1055/s-2007-971529
  17. Sushilkumar, Bagchi, G.D., Darokar, M.P., and Kumar, S. Antibacterial activity observed in the seeds of some corpophilous plants. Int. J. Pharmacog. 35, 179-184 (1997) https://doi.org/10.1076/phbi.35.3.179.13293
  18. Shay, H., Komarov, S.A., Fels, S.E., Meraze, D., Gruenstein, M., and Siplet, H.A., Simple method for the uniform production of gastric ulceration. Gastroenterology 5, 43-61 (1945)
  19. Yesilada, E., Gurbutz, I., and Ergun, E., Effect of Cistus laurifolius L. flowers on gastric and duodenal lesions. J. Ethnopharmacol. 55, 201-211 (1997) https://doi.org/10.1016/S0378-8741(96)01502-4