Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Rubus coreanus Unripe Fruits Inhibits Immediate-type Allergic Reaction and Inflammatory Cytokine Secretion

  • Shin, Tae-Yong (Dept. of Pharmacy, College of Pharmacy, Woosuk University) ;
  • Shin, Hye-Young (Dept. of Pharmacy, College of Pharmacy, Woosuk University) ;
  • Kim, Sang-Hyun (Dept. of Pharmacology, School of Medicine, Kyungpook National University) ;
  • Kim, Dae-Keun (Dept. of Pharmacy, College of Pharmacy, Woosuk University) ;
  • Chae, Byeong-Suk (Dept. of Pharmacy, College of Pharmacy, Woosuk University) ;
  • Oh, Chan-Ho (Dept. of Food Biotechnology, Woosuk University) ;
  • Cho, Moon-Gu (Dept. of Food Biotechnology, Woosuk University) ;
  • Oh, Suk-Heung (Dept. of Food Biotechnology, Woosuk University) ;
  • Kim, Jong-Hwa (Dept. of Pharmaceutical Engineering, Woosuk University) ;
  • Lee, Tae-Kyoo (Dept. of Food Industry & Management, Woosuk University) ;
  • Park, Jeong-Suk (Dept. of Oriental Alternative Medicine, Nambu University)
  • Published : 2006.09.01
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Abstract

The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq.(Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor $(TNF)-{\alpha}$ and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.

Keywords

References

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