The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Anti-histamic Effect and IL-4 and GM-CSF mRNA Expression on Sungmagalkun-tang

升麻葛根湯의 항히스타민 효과 및 IL-4와 GM-CSF 발현에 미치는 영향

  • Kim, Hong-Bae (Department of Pediatrics, College of Oriental medicine, Dongeui University) ;
  • Kim, Own-Il (Department of Internal medicine, College of Oriental medicine, Dongeui University) ;
  • Lee, Seung-Yeon (Department of Pediatrics, College of Oriental medicine, Dongeui University,Clinical Research Center of Oriental Medicine, Dongeui University)
  • 김홍배 (동의대학교 한의과대학 소아과학교실) ;
  • 김원일 (동의대학교 한의과대학 비계내과학교실) ;
  • 이승연 (동의대학교 한의과대학 소아과학교실,동의대학교 임상연구센터)
  • Published : 2006.04.30
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Abstract

We investigated the effect of Sungmagalkun-tang (SGT) on the allergy. We conformed compound 48/80-induced active systemic anaphylatic shock, anti-dinitrophenyl IgE-mediated passive cutaneous anaphylaxis and ovalbumin-induced anaphylatic shock. Also observed IL-4 and GM-CSF mRNA expression in ovalbumin-induced allergic lung tissue and RBL-2H3. Histamine release is measured in RBL-2H3. SGT inhibited active systemic anaphylatic shock, passive cutaneous anaphylaxis and ovalbumin-induced anaphylatic shock by oral administration. We observed that SGT was concentration-dependently reduced IL-4 and GM-CSF mRNA expression in ovalbumin-induced allergic lung tissue and RBL-2H3 by SGT. In addition, SGT reduced histamine release in RBL-2H3. These results indicate that SGT has anti-histamic effect and controls IL-4 and GM-CSF mRNA expression on allergy.

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