The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)
- Volume 20 Issue 1
- /
- Pages.69-83
- /
- 2006
- /
- 1226-8038(pISSN)
- /
- 2287-9463(eISSN)
Anti-histamic Effect and IL-4 and GM-CSF mRNA Expression on Sungmagalkun-tang
升麻葛根湯의 항히스타민 효과 및 IL-4와 GM-CSF 발현에 미치는 영향
- Kim, Hong-Bae (Department of Pediatrics, College of Oriental medicine, Dongeui University) ;
-
Kim, Own-Il
(Department of Internal medicine, College of Oriental medicine, Dongeui University) ;
-
Lee, Seung-Yeon
(Department of Pediatrics, College of Oriental medicine, Dongeui University,Clinical Research Center of Oriental Medicine, Dongeui University)
- Published : 2006.04.30
Abstract
We investigated the effect of Sungmagalkun-tang (SGT) on the allergy. We conformed compound 48/80-induced active systemic anaphylatic shock, anti-dinitrophenyl IgE-mediated passive cutaneous anaphylaxis and ovalbumin-induced anaphylatic shock. Also observed IL-4 and GM-CSF mRNA expression in ovalbumin-induced allergic lung tissue and RBL-2H3. Histamine release is measured in RBL-2H3. SGT inhibited active systemic anaphylatic shock, passive cutaneous anaphylaxis and ovalbumin-induced anaphylatic shock by oral administration. We observed that SGT was concentration-dependently reduced IL-4 and GM-CSF mRNA expression in ovalbumin-induced allergic lung tissue and RBL-2H3 by SGT. In addition, SGT reduced histamine release in RBL-2H3. These results indicate that SGT has anti-histamic effect and controls IL-4 and GM-CSF mRNA expression on allergy.