YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antioxidative Activity of Water Extract of Different Parts of Acanthopanax divaricatus var, albeofructus

흰털오가피 부위별 물추출물의 항산화활성

  • Lyu, Su-Yun (College of Natural Sciences, Seoul Women's University) ;
  • Kim, Ji-Young (College of Natural Sciences, Seoul Women's University) ;
  • Noh, Bin-Na (College of Natural Sciences, Seoul Women's University) ;
  • Park, Won-Bong (College of Natural Sciences, Seoul Women's University)
  • 유수연 (서울여자대학교 자연과학대학) ;
  • 김지영 (서울여자대학교 자연과학대학) ;
  • 노빛나 (서울여자대학교 자연과학대학) ;
  • 박원봉 (서울여자대학교 자연과학대학)
  • Published : 2006.06.30
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Abstract

Acanthopanax species have traditionally been used as a tonic, a sedative as well as in the treatment of rheumatism, hypertension and diabetes. In the present study, oxidative stress was induced in Vero cells by incubating the cells with glucose and the cell viability was measured by MTT assay. The concentration of glucose which 50% of cell viability was 125 mM $(IC_{50})$ and the cell viability was increased to $87.6{\pm}8.8%$ by treatment of the extracts of Acanthopanax divaricatus var. albeofructus. The antioxidative activity of water extract of different parts of the Acanthopanax plant was investigated by DPPH (1,1-diphenyl-2-picrylhydrazyl) assay, xylenol orange assay, TBARS (thiobarbituric acid reactive substances) assay and enzyme (superoxide anion and catalase) assay. Each extract (leaves, root, stem and fruits) of the plant showed free radical and $H_2O_2$ scavenging activity. The extract also inhibited lipid peroxidation and recovered enzyme (superoxide anion dismutase and catalase) activity in Vero cells treated with glucose.

Keywords

References

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