대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

제습순기탕(除濕順氣湯)이 고지혈증(高脂血症) 병태(病態) 모델에 미치는 영향(影響)

The Effect of Jeseubsungi-tang on Dietary Hyperlipidemia-induced Mice

  • 김정현 (대전대학교 한의과대학 내과학교실) ;
  • 조현경 (대전대학교 한의과대학 내과학교실) ;
  • 유호룡 (대전대학교 한의과대학 내과학교실) ;
  • 설인찬 (대전대학교 한의과대학 내과학교실) ;
  • 김윤식 (대전대학교 한의과대학 내과학교실)
  • Kim, Jung-Hyun (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Jo, Hyun-Kyung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Yoo, Ho-Rhyong (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Seol, In-Chan (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Kim, Yoon-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
  • 발행 : 2006.03.30
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초록

Objectives : This experiment was performed to determine the effects of the Jeseubsungi-tang(JSSGT) on hyperlipidemia-induced by hypercholesterolemic diet in mice. Methods : C57BL/6 mice were sensitized with a hypercholesterolemic diet for 6 weeks. Experimental group was treated with $150mg/d{\ell}$ concentrations of JSSGT for 4 weeks (once a day). Results: JSSGT-treated mice showed a body weight decrease compared to normal group. JSSGT-treated mice showed a significant decrease in cholesterol, total cholesterol, triglyceride, ALT and LDL-cholesterol levels compared to hyperlipidemia-induced control group. However, HDL-cholesterol levels in JSSGT-treated group significantly increased compared to the hyperlipidemia-induced control group. Conclusion : These results suggest that JSSGT is effective in treating hyperlipidemia. Because only hyperlipidemic mice were studied, further research is needed.

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