Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Regulatory Effect of Gigukjihwangtanggami on Cytokine Production in Patients with Cerebral Infarction

  • Lee, Min-Goo (Department of Internal Medicine, College of Oriental Medicine,Department of 3rd Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Park, Sae-Wook (Department of Internal Medicine, College of Oriental Medicine,Department of 3rd Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Sun-Woo (Department of Internal Medicine, College of Oriental Medicine,Department of 3rd Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Son, Ji-Woo (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Baek-Gyu (Department of Internal Medicine, College of Oriental Medicine,Department of 3rd Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Park, Sang-Moo (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee, In (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon, Byung-Soon (Department of Internal Medicine, College of Oriental Medicine,Department of 3rd Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • Published : 2006.08.25
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Abstract

The Korean genuine medicine, 'Gigukjihwangtanggami (GJT)' has long been used clinically for hypertension and various cerebrovascular diseases. However, experimental study has been carried out very little. Recently cytokines involved in the regulation of inflammatory reactions and immune responses may play an important role in the pathogenesis of cerebral infarction (CI). The aim of this study is to investigate the effect of GJT on the production of pro-inflammatory cytokines and anti-inflammatory cytokines in peripheral blood mononuclear cells (PBMCS) stimulated with lipopolysaccaride (LPS) from Cl patients. The amount of tumor necrosis $factor-{\alpha}\;(TNF-{\alpha}),\;interleukin-1{\beta}\;(IL-1{\beta})$, IL-6, IL-8, IL-4 and IL-10 in PBMC culture supernatant was significantly increased in the LPS treated cells compared to unstimulated cells. GJT inhibited the production of $TNF-{\alpha},\;IL-1{\beta}$, IL-6 and IL-8 induced by LPS. The maximal inhibition rate of the $TNF-{\alpha},\;IL-1{\beta}$, IL-6 and IL-8 production by pretreatment of GJT (1 mg/ml) was $57.32{\pm}2.5%$ (p.0.05), $42.02{\pm}3.5%$ (p.0.05), $40.02{\pm}2.3%$ (p.0.05) and $48.02{\pm}3.1$, (p.0.05), respectively. In the Other hand, GJT increased the production of IL-4 and IL-10. The maximal increase rate of the IL-4 and IL-10 production by pretreatment of GJT (1 mg/ml) was $42.4{\pm}3.3%$ (p.0.05) End $56.4{\pm}2.9%$ (p.0.05), respectively. Taken together, these results indicate that GJT Ray have regulatory effects on the cytokine production and suggest that GJT might use clinically for the treatment of CI.

Keywords

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