Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Electro-acupuncture and Therapeutic Exercise on Nervous system in the Ischemic Stroke Rats

전침자극과 운동치료가 허혈성 뇌졸중 백서모델의 신경계에 미치는 영향

  • Yoo, Young-Dae (Department of rehabilitation medicine, Wonkwang University Medical Center) ;
  • Kim, Gi-Do (Department of Physical Therapy of Dongshin University) ;
  • Chun, Jin-Sung (Department of Physical Therapy of Dongshin University) ;
  • Jeong, Hyun-Woo (Department of Oriental Medicine of Dongshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy of Dongshin University)
  • 유영대 (원광대학교 광주한방병원) ;
  • 김기도 (동신대학교 물리치료학과) ;
  • 천진성 (동신대학교 물리치료학과) ;
  • 정현우 (동신대학교 한의학과) ;
  • 김계엽 (동신대학교 물리치료학과)
  • Published : 2006.08.25
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Abstract

This study was intended to examine the effects of electroacupuncture(EA) and therapeutic exercise on the improvement of exercise function, BNDF, and HSP70 protein expression in an ischemic stroke model induced by MCA occlusion. Experiments were conducted for 1, 3 days, 1, 8 weeks respectively. Group I was a group of EA and therapeutic exercise; Group II was a group of therapeutic exercise; Group III was a group of EA; Group IV was a sham group of EA; Group V was a control group; and Group VI was a sham group without ischemic stroke. In each group, neurologic motor behavior test, histologic observations, BDNF, and HSP70 expression were observed and analyzed. The following results were obtained. The results of behavior test suggest that 8 weeks after ischemic stroke was induced, Group I improved in degeneration and inflammation of muscle fiber and decreased in destruction of nerve cells and cerebral infarction, indicating a similar state of muscle fiber and brain to Group VI. In immunohistochemical observations, Group I showed increase in BDNF and decrease in HSP70. Based on these results, EA and therapeutic exercise may improve muscle atrophy and change in BDNF and HSP70 expression of ischemic stroke rats and contribute to the improvement of exercise function.

Keywords

References

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