Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Danchunwhangagam on LPS or DFX-induced Cytokine Production in Peripheral Mononuclear Cells of Cerebral Infarction Patients

단천환가감이 중풍 환자의 말초 단핵구에서 LPS 및 DFX 유도성 사이토카인 생성에 미치는 영향

  • Lee, Seoung-Geun (Department of International Medicine of Oriental Medicine Hospital, Wonkwang University) ;
  • Lee, Key-Sang (Department of International Medicine of Oriental Medicine Hospital, Wonkwang University)
  • 이성근 (원광대학교 산본한방병원 내과) ;
  • 이기상 (원광대학교 산본한방병원 내과)
  • Published : 2006.08.25
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Abstract

This study was to investigate the effect of Danchunwhangagam(DCWGG) extract on the production of proinflammatory cytokines in peripheral mononuclear cells (PBMCS) from Cerebral infarction(CI) patients. Methods: We examined that the inhibition rate of tumor necrosis factor $(TNF)-{\alpha},\;interleukin(IL)-1{\alpha},\;IL-1{\beta}$, IL-6, and IL-8 productions in DCWGG pretreatment PBMCs culture supernatant in the lipopolysaccaride(LPS)- or Oesferrioxamine(DFX)-treated cells compared to unstimulated cells. DCWGG inhibited the productions of $TNF-{\alpha},\;IL-1{\alpha},\;IL-1{\beta}$, IL-6, and IL-8 induced by LPS in a dose-dependent manner DCWGG might have regulatory effects on LPS or DFX-induced cytokine production, which might explain its beneficial effect in the treatment of CI.

Keywords

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