Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Acanthopanax Sessiliflorus $S_{EEM}$ Ethyl Alcohol Extract on the Cerebral Blood Flow and Mean Arterial Blood Pressure in Normal & Ischemic Rats

오갈피 에탄올 추출물이 뇌혈류 및 혈압에 미치는 효과

  • Published : 2006.08.25
Download PDF
⟨ Previous Next ⟩

Abstract

This study was designed to investigate the effects of Acanthopanax sessiliflorus 5.,M (ASS) on the regional cerebral blood flow (rCBF) and mean arterial blood pressure (BP) in normal rats and ischemic rats. Experimental groups of rCBF and BP in normal and ischemic rats as follows ; ALE was injected ASS leaves 45% ethyl alcohol extract, ASE was injected ASS stems 45% ethyl alcohol extract, ARE was injected ASS roots 45% ethyl alcohol extract. The results were as follows ; In normal rats, ALE and ARE significantly increased rCBF in a dose-dependent manner, but ASE significantly decreased rCBF and MABP in a dose-dependent manner, ALE increased MABP In ischemic rats, rCBF was significantly and staDly improved by ARE (10 mg/kg, i.p.) during the period of cerebral reperfusion, which was contrasted with the findings of rapid and marked increase in control group. From the above results, it was thought that all part of Acanthopanax sessiliflorus $S_{EEM}$ was effective for hemodynamics and especially ARE was more effective than other parts.

Keywords

References

  1. 杜鎬京. 東醫腎系學, 東洋醫學硏究院, 서울, pp 1075-1080, 1082-1083, 1991
  2. 나영설, 윤상협, 민병일.最近 腦卒中에 대한 力學的 考察, 慶熙醫學 7:280-286, 1991
  3. Kety, S.S., Schmidt, C.F. The nitrous oxide method for the man ; theory, procedure and normal values, J. Clin Invest. 27:476-483, 1948 https://doi.org/10.1172/JCI101994
  4. Sharbrough, F.W., Messick, M.K. Jr, Sundt, T.M. Jr. Correlation of continnous electroencephalograms with cerebral blood flow measurments during carotid endarterectomy, Stroke 4:672-683, 1973
  5. Trojaborg, W., Boysen, G. Relation between EEG, regional cerebral blood flow and internal carotid artery pressure during carotid endarterectomy, Electroencephalogr Clin Neurophysiol. 34:61-69, 1973 https://doi.org/10.1016/0013-4694(73)90151-X
  6. Harris, R.J., Symon, L., Branston, N.M., Bayhan, M. Changes in extracellular calcium activity in cerebral ischemia, J. Cereb Blood Flow Metab. 1:203-209, 1981 https://doi.org/10.1038/jcbfm.1981.21
  7. Wieloch, T., Siesjo, B.K. Ischemic brain injury ; the importance of calcium, lipolytic activities and free fatty acids, Pathol Biol(Paris). 30:269-277, 1982
  8. 이경은, 김경환. 허혈, 재관류 손상에서 뇌조직 아민 변동과 Free Radical과의 관련성, 大韓神經科學會誌 8(1):2-8, 1990
  9. 全國韓醫科大學 本草學敎授 共編 : 本草學, 永林社, 서울, pp 283-284, 1999
  10. 이인중, 김길웅. 약용식물(음나무, 오가피)로부터 생리활성 물질 검정, 한국잡초학회 7(3):289-299, 1987
  11. 정종운, 이윤호, 강성길. 가시오가피 약침이 당뇨유발 억제 및 신장보호 활성에 미치는 영향, 대한침구학회지 20(3):1-14, 2003
  12. 김호철, 이상인, 안덕균. Human Monocyte의 IL-8 생산억제에 미치는 류마토이드관절염 치료제로서의 오가피의 효과, 대한본초학회지 10(1):49-59, 1995
  13. 정현우, 노영호, 이금수, 김천중, 전병관. 오가피 추출액이 면역, 항암 및 비만에 미치는 실험적 효과, 동의생리병리학회지, 19(2):389-397, 2005
  14. Chen, S.T., Hsu, C.Y., Hogan, E.L., Maricque, H., Balentine, J.D. A model of focal ischemic stoke in the rat ; reproducible extension cortical infarction, Stroke 17:738-743, 1986 https://doi.org/10.1161/01.STR.17.4.738
  15. Longa, E.Z., Weinstein, P.R., Carlson, S., Cummins, R. Reversible middle cerebral artery occlusion without craniectomy in rats, Stroke 20(1):84-91, 1989 https://doi.org/10.1161/01.STR.20.1.84
  16. 康秉秀, 金永坂 共編著. 方劑의 體系的 構成을 위한 臨床配合本草學, 永林社, 서울, pp 644-645, 1996
  17. 대한신경외과학회. 신경외과학, 중앙문화사, 서울, pp 150-156, 275-276, 1998
  18. 서울대학교 의과대학 내과학교실편. 내과학, 군자출판사, 서울, pp 146-158, 1996
  19. 李文鎬, 金鍾暉, 許仁穆. 內科學(上), 學林社, 서울, pp 77-81, 1986
  20. 金祐謙. 인체의 생리, 서울대학교 출판부, 서울, pp 30-47, 107-118, 1985
  21. McCord, J.M. Mechanisms of disease : oxygen-derived free radicals in postischemic tissue injury, New Eng J. Med. 312:159-163, 1985 https://doi.org/10.1056/NEJM198501173120305
  22. Cheung, J.Y., Bonventre, J.V., Malis, C.D., Leaf, A. Mechani는 of disease ; calcium and ischemic injury, New Eng J. Med. 26:1670-1676, 1986
  23. Weisfeldt, M.L. Reperfusion and Reperfusion injury, Clin Res. 35:13-20, 1987
  24. Hallenbeck, J.M., Dutka, A.J., Tanishima, T., Kochanek, P.M., Kumaroo, K.K., Thompson, C.B., Obrenovich, T.P., Contreras, T.J. Polymorphonuclear leukocyteaccumulation in brain region with low blood flow during the early postischemic period, Stroke 17:246-253, 1986 https://doi.org/10.1161/01.STR.17.2.246
  25. Garcia, J.H., Liu, K.F., Yoshida, Y., Lian, J., Chen, S., del Zoppo, G.J. Influx of leukocytes and platelets in an evolving brain infarct(Wistar rat), Am J. Pathol. 144:188-199, 1994