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Effects of Acanthopanax Sessiliflorus $S_{EEM}$ Ethyl Alcohol Extract on the Cerebral Blood Flow and Mean Arterial Blood Pressure in Normal & Ischemic Rats  

Rho, Young-Ho (College of Oriental Medicine, Dongshin University)
Jeon, Byung-Gwan (Department of Environmental Engineering, Dongshin University)
Jeong, Hyung-Woo (College of Oriental Medicine, Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.4, 2006 , pp. 882-886 More about this Journal
Abstract
This study was designed to investigate the effects of Acanthopanax sessiliflorus 5.,M (ASS) on the regional cerebral blood flow (rCBF) and mean arterial blood pressure (BP) in normal rats and ischemic rats. Experimental groups of rCBF and BP in normal and ischemic rats as follows ; ALE was injected ASS leaves 45% ethyl alcohol extract, ASE was injected ASS stems 45% ethyl alcohol extract, ARE was injected ASS roots 45% ethyl alcohol extract. The results were as follows ; In normal rats, ALE and ARE significantly increased rCBF in a dose-dependent manner, but ASE significantly decreased rCBF and MABP in a dose-dependent manner, ALE increased MABP In ischemic rats, rCBF was significantly and staDly improved by ARE (10 mg/kg, i.p.) during the period of cerebral reperfusion, which was contrasted with the findings of rapid and marked increase in control group. From the above results, it was thought that all part of Acanthopanax sessiliflorus $S_{EEM}$ was effective for hemodynamics and especially ARE was more effective than other parts.
Keywords
Acanthopanax sessiliflorus $S_{EEM}$; regional cerebral blood flow; blood pressure; ischemica;
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