Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Apoptosis-inducing Effect of Takrisodokyeum Extract in Androgen Independent Prostate Cancer Cells

남성호르몬 비의존형 전립선 암세포에서 탁리소독음(托裏消毒飮) 추출물의 세포고사 유도 효과

  • Lee, Hyung-Jae (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kwon, Kang-Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Byung-Cheul (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Eun-Kyung (Department of Biochemistry, College of Medicine, Chonbuk National University Medical School) ;
  • Han, Mi-Jeong (Department of Biochemistry, College of Medicine, Chonbuk National University Medical School) ;
  • Song, Mi-Young (Department of Biochemistry, College of Medicine, Chonbuk National University Medical School) ;
  • Lee, Young-Rae (Department of Biochemistry, College of Medicine, Chonbuk National University Medical School) ;
  • Park, Byung-Hyun (Department of Biochemistry, College of Medicine, Chonbuk National University Medical School) ;
  • Ryu, Do-Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
  • 이형재 (원광대학교 한의과대학 생리학교실) ;
  • 권강범 (원광대학교 한의과대학 생리학교실) ;
  • 신병철 (원광대학교 한방재활의학교실) ;
  • 김은경 (전북대학교 의과대학 생화학교실) ;
  • 한미정 (전북대학교 의과대학 생화학교실) ;
  • 송미영 (전북대학교 의과대학 생화학교실) ;
  • 이영래 (전북대학교 의과대학 생화학교실) ;
  • 박병현 (전북대학교 의과대학 생화학교실) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실)
  • Published : 2006.08.25
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Abstract

Takrisodokyeum (TRSDY) has been known to exert anti-tumoral activity in Korea. However, its molecular mechanism of action is not understood. In this study, we found that TRSDY induced apoptosis in androgen-independent prostate cancer DU145 cells as evidenced by DNA fragmentation and chromatine condensation in hoechst 33342 dye staining. Our data demonstrated that TRSDY-induced apoptotic cell death was accompanied by increases of PTEN and Par-4 in a time-dependent manner Taken together, these results suggest that TRSDY induce PTEN and Par-4 expression, and eventually lead to apoptotic cell death in androgen independent prostate cancer DU145 cells.

Keywords

References

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