Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Sopung-san on Contact Hypersensitivity induced by Repeat Elicitation of DNCB

소풍산물추출물이 DNCB로 유발된 접촉성피부염에 미치는 영향

  • Park, Sook-Jahr (Department of prescription, College of Oriental Medicine, Daegu Hanny University) ;
  • Lee, Sang-Gon (Department of Ophthalmology and Otorhinolaryngology and Dermotology, College of Oriental Medicine, Daegu Hanny University) ;
  • Baek, Jung-Han (Department of Pediatries, College of Oriental Medicine, Daegu Hanny University) ;
  • Byun, Sung-Hui (Department of prescription, College of Oriental Medicine, Daegu Hanny University) ;
  • Kim, Sang-Chan (Department of prescription, College of Oriental Medicine, Daegu Hanny University)
  • 박숙자 (대구한의대학교 한의과대학 방제학교실) ;
  • 이상곤 (대구한의대학교 한의과대학 외관과) ;
  • 백정한 (대구한의대학교 한의과대학 소아과) ;
  • 변성희 (대구한의대학교 한의과대학 방제학교실) ;
  • 김상찬 (대구한의대학교 한의과대학 방제학교실)
  • Published : 2006.06.25
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Abstract

Sopung-san(SPS; prescription No. DO27), a herbal medicine prescribed by oriental hospital of Daegu fanny University, has been used as cure for pruritus and psoriasis. To evaluate anti-inflammatory effect of Sopung-san, we treated Sopung-san extract in animal model system induced contact hypersensitivity. Contact hypersensitivity, a local inflammatory response of the skin, was induced by 1% DNCB on the right ear of BALB/C mouse. Sopung-san was prepared as water extract and administrated everyday for 2 weeks per oral. A right ear of mouse was potently swelled by 1% of DNCB treatment, but a mouse ear thickness was significantly reduced by Sopung-san after 2 weeks. treatment. Sopung-san reduced IgG in serum obtained from blood of 1 % DNCB-treated mouse. IgE in serum was not changed by DNCB and/or Sopung-san treatment. $IL-1{\beta}$ and IL-6 from ear tissue were significantly increased by DNCB, Dut were not reduced by Sopung-san. From these results, anti-inflammatory effect of Sopung-san, especially reduction of ear swelling, might be partly due to reduction of IgG in serum.

Keywords

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