Immunostimulating Effects of Acanthopanax in mice following Gamma-ray irradiation

방사선 조사 마우스에서 오가피의 면역활성 효과

  • Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University) ;
  • Jeong, Hyun-Woo (Department of Pathology, college of Oriental Medicine of Dongshin University) ;
  • Kim, Kyung-Yoon (Department of Physical Therapy, Dongshin University)
  • 김계엽 (동신대학교 물리치료학과) ;
  • 정현우 (동신대학교 한의과대학 병리학교실) ;
  • 김경윤 (동신대학교 물리치료학과)
  • Published : 2006.06.25

Abstract

This experimental study was carried out to investigate the immunostimulating effect of Acanthopanax, as Oriental rhizomata herbs, on jejunal survival, endogenous spleen colony formation, apoptosis in jejunal crypt cells and lipid peroxidation in the liver of mice following Gamma-ray irradiation. The subject of this study includes 72 mice which were divided into each 7 groups. Acanthopanax experiment groups were Acanthopanax. Gamma-ray(lOGy), Acanthopanax. Gamma-ray(3Gy), Acanthopnax. Gamma-ray(1Gy), Gamma-ray control(1OGy), Gamma-ray control(3Gy), Gamma-ray control(1Gy), Normal groups. The results of this study were as follows : Treatment with Acanthopanax showed significantly increased(p<0.05) on the cell death apoptosis in crypt, intestine crypts survival of intestine in mice following low-dose(1Gy) Gamma-ray radiation. And that significantly increased(p<0.05) on jejunal crypt survival and reduced(p<0.05) on lipid peroxidation in mice following high-dose(1OGy) Gamma-ray radiation. The above results suggest that Acathopanax were immunostimulating effectively reduced Gamma-ray irradiation.

Keywords

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