Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Protective Effects of Iljungbogan-Tang on Acute Hepatotoxicity Induced by $CCL_4$ and Acetaminophen

급성 간독성에 대한 일중보간탕(一中補肝湯)의 해독 효과에 관한 연구

  • Kim, Joon-Myoung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Park, Yang-Chun (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Son, Gi-Jung (Il Jung Oriental medicine clinic)
  • 김준명 (대전대학교 한의과대학 폐계내과학교실) ;
  • 박양춘 (대전대학교 한의과대학 폐계내과학교실) ;
  • 손기정 (일중한의원)
  • Published : 2006.04.25
Download PDF
⟨ Previous Next ⟩

Abstract

This study was done to investigate the protective effects of Iljungbogan-Tang on acute hepatotoxicity of rats induced by $CCL_4$ and acetaminophen. The subject animals were divided into 3 groups : control group(administrated 0.5% carboxymethyl cellulose), sample group(30, 100, 300, 600mg/kg administrated), positive control group (administrated silymarine), Acute hepatotoxicity of rats were induced by $CCL_4$ and acetaminophen, and the serum transaminase(AST, ALT) were measured for enzyme activities. The inhibitory effects on the serum AST activities were noted in sample group(100, 300, 600mg/kg administrated) on hepatotoxicity of rats induced by $CCL_4$. The inhibitory effects on the serum AST, ALT activities were noted in sample group(30mg/kg administrated) on hepatotoxicity of rats induced by acetaminophen. The inhibitory effects on the serum AST activities were noted in sample group(600mg/kg single dose administrated) on hepatotoxicity of rats induced by acetaminophen. It is considered that Iljungbogan-Tang has protective effects against hepatotoxicity in rats induced by $CCL_4$ and acetaminophen. So it is required to study about the actions of mutual relation of medicines and patho-mechanism through experiment.

Keywords

References

  1. 통계청. 2000년도 사망원인통계결과. 서울, 통계청. 2001
  2. 전국한의과대학 간계내과교수저. 간계내과학. 서울, 동양의학연구원. pp 24-29, 230-231, 1995
  3. 고려의학편집부. 소화기 질환. 서울:고려의학. 1989:144-192
  4. 서광의학서림편집부. 간장병의 진단학. 광주, 서광의학서림. pp 115-117, 375-376, 439-447, 1991
  5. 김완희, 최달영. 장부변증논치. 서울, 성보사. pp 70-74, 87, 105-109, 139-140, 150-165, 1982
  6. 이태훈, 강재춘, 김병우. 흰쥐의 간손상에 대한 가감인작도화탕의 간 보호효과. 대한한방내과학회지 24(1):44-54, 2003
  7. 의학계열교수 27인 공역. 의학생리학. 서울: 도서출판정담. 2002:928-30
  8. 김정제, 김병운. 동의진료요감. 서울, 동양의학연구원 pp 24-29, 230-231, 1983
  9. 최은주, 강재춘. 舟車丸이 CCL4 및 d-galactosamine으로 유발된 흰쥐의 肝損傷에 미치는 영향. 대한한방내과학회 24(1):55-67, 2003
  10. 전국한의과대학 본초학교실. 본초학. 서울, 영림사. pp 291, 294, 305, 327-329, 347, 369, 414, 417, 536, 1991
  11. 신동훈, 조명래. 지구자에 대한 문헌고찰 및 최근 연구동향. 대한본초학회지 17(1):81-91, 2002
  12. Mathnew, J.E., Donald, G.B. Medical Toxicology, Diagnosis and Treatment of Human Poisoning. Elsevier. pp 969-972, 1963
  13. Gordis, E. Lipid metabolites of carbon tetrachloride. J. Clin. Invest. 48, 203-209, 1969 https://doi.org/10.1172/JCI105969
  14. Pohl, L., Schulick, R., Highet, R., George, J. Identification of dichloromethyl carbene as a metabolite of carbon tetrachloride. Biochem. Biophys. Res. Commun. 117, 367-372, 1983 https://doi.org/10.1016/0006-291X(83)91209-3
  15. Noll, T., Groot, H. The critical steady-state hypoxic conditions in carbon tetracholoride-induced lipid peroxidation in rat liver microsomes. Biochem. Biophys. Acta. 795, 356-362, 1984 https://doi.org/10.1016/0005-2760(84)90086-9
  16. Geerts, A., Schelhnck, P., Bouwens, L., Wisse, E. Cell population kinetics of kupffer cells during the onset of fibrosis in rat liver by chronic carbon tetrachloride administration. J. Hepatol. 6, 50, 1988 https://doi.org/10.1016/S0168-8278(88)80461-6
  17. Hoyumpa, A.M. Jr., Green, H.L., Dunn, G.D., Schenker, S. Fatty liver.: Biochemical and clinical considerations. Am. J. Dig. Dis. 20, 1142-1163, 1975 https://doi.org/10.1007/BF01070758
  18. Lombardi, B. Considerations on the pathogenesis of fatty liver. Lab. Investe. 15, 1, 1966
  19. Stewart, R.D., Boettner, E.A., Southworth, R.R., et al. Acute carbon tetrachloride intoxication. JAMA. 183, 994-997, 1963 https://doi.org/10.1001/jama.1963.03700120052008
  20. Mitchell, J.R., Jollow, D.J., Gillette, J.R., Brodie, B.B. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp. Ther. 187, 211-217, 1973