Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Antibacterial Activity of 1β-Methyl-2-[5-(α,β-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem Derivatives. Part II

  • Kim, Jin-Woong (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Park, Hyeong Beom (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Chung, Bong Young (Department of Chemistry, Korea University) ;
  • Lee, Jong Baek (Department of Chemical Engineering, Dongeui University) ;
  • Cho, Jung-Hyuck (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Oh, Chang-Hyun (Medicinal Chemistry Research Center, Korea Institute of Science and Technology)
  • Published : 2006.08.20
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Abstract

The synthesis of a new series of 1$\beta$-methylcarbapenems having 5-($\alpha,\beta$-disubstituted ethyl)pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (VIh) having $\alpha$-hydroxy-$\beta$-piperazinylethyl substituted moiety showed the most potent activity.

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References

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