Tuberculosis and Respiratory Diseases

  • 제59권2호
  • /
  • Pages.157-163
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  • 2005
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  • 1738-3536(pISSN)
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  • 2005-6184(eISSN)
대한결핵및호흡기학회 (The Korean Academy of Tuberculosis and Respiratory Diseases)
권호 표지

한국인에서 Myeloperoxidase (MPO) 유전자의 -463G>A 다형성과 원발성 폐암의 위험도

Myeloperoxidase -463G>A Polymorphism dose not Contribute to the Risk of Primary Lung Cancer in a Korean Population

  • 박재형 (경북대학교 의과대학 내과학교실) ;
  • 박정민 (경북대학병원 암연구센터) ;
  • 김은진 (경북대학교 의과대학 내과학교실) ;
  • 윤석진 (경북대학교 의과대학 내과학교실) ;
  • 이승준 (경북대학교 의과대학 내과학교실) ;
  • 차승익 (경북대학교 의과대학 내과학교실) ;
  • 이응배 (경북대학교 의과대학 흉부외과학교실) ;
  • 김창호 (경북대학교 의과대학 내과학교실) ;
  • 감신 (경북대학교 의과대학 예방의학교실) ;
  • 김동선 (경북대학교 의과대학 해부학교실) ;
  • 정태훈 (경북대학교 의과대학 내과학교실) ;
  • 박재용 (경북대학교 의과대학 내과학교실)
  • Park, Jae Hyoung (Department of Internal Medicine, Kyungpook National University Hospital) ;
  • Park, Jung Min (Cancer Research Institute, School of Medicine, Kyungpook National University) ;
  • Kim, Eun Jin (Department of Internal Medicine, Kyungpook National University Hospital) ;
  • Yun, Suk Jin (Department of Internal Medicine, Kyungpook National University Hospital) ;
  • Lee, Sung Jun (Department of Internal Medicine, Kyungpook National University Hospital) ;
  • Cha, Sung Ick (Department of Internal Medicine, Kyungpook National University Hospital) ;
  • Lee, Eung Bae (Department of Thoracic Surgery, Kyungpook National University Hospital) ;
  • Kim, Chang Ho (Department of Internal Medicine, Kyungpook National University Hospital) ;
  • Kam, Sin (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Kim, Dong Sun (Department of Anatomy, School of Medicine, Kyungpook National University) ;
  • Jung, Tae Hoon (Department of Internal Medicine, Kyungpook National University Hospital) ;
  • Park, Jae Yong (Department of Internal Medicine, Kyungpook National University Hospital)
  • 투고 : 2005.05.02
  • 심사 : 2005.07.18
  • 발행 : 2005.08.30
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초록

목 적 : Myeloperoxidase (MPO)는 benzo(a)pyrene, aromatic amines과 같은 발암전구물질 활성화를 통해 폐암 발생에 관여한다. MPO 유전자 promoter 부위의 -463G>A 다형성은 MPO유전자의 발현량을 감소시킨다고 알려져 있다. 저자들은 MPO 유전자 promoter 부위의 -463G>A 다형성과 폐암 위험도의 상관 관계를 조사하였다. 방 법 : 경북대학교병원에서 폐암으로 진단된 432예를 대상으로 하였으며 대조군은 건강검진센타를 방문한 건강인 가운데 환자군과 연령 및 성을 match하여 무작위로 선택한 432명을 대상으로 하였다. 결 과 : MPO -463G>A의 유전자형은 폐암군의 경우 GG, GA, AA형이 각각 353명(81.7%), 76명(17.6%), 3명(0.7%)이였고 대조군의 경우 각각 356명(82.4%), 72명(16.7%), 4명(0.9%)으로 두 군간에 유의한 차이가 없었다. -463 AA+GA 유전자형은 -463 GG 유전자형에 비해 전체 폐암의 경우 위험도의 유의한 차이가 없었으며 (adjusted OR= 1.03, 95% CI= 0.72-1.47), 연령, 성별, 흡연력, 조직형으로 구분하였을 경우에도 유의한 차이가 없었다. 결 론 : MPO 유전자의 -463G>A 다형성은 한국인에서 폐암의 위험도를 결정하는 주요 인자가 아닌 것으로 생각된다.

키워드

참고문헌

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