Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Lambert-Eaton Myasthenic Syndrome with Positive VGCC Antibodies Diagnosed in Small Cell Lung Cancer

소세포폐암환자에서 진단된 VGCC 항체 양성인 Lambert-Eaton 근무력 증후군 1예

  • Kim, So Young (Department of Internal Medicine, College of Medicine Wonkwang University) ;
  • Oh, Hyo Jeong (Department of Internal Medicine, College of Medicine Wonkwang University) ;
  • Hwang, Ki Eun (Department of Internal Medicine, College of Medicine Wonkwang University) ;
  • Jung, Jong Hoon (Department of Internal Medicine, College of Medicine Wonkwang University) ;
  • Kim, Hak Ryul (Department of Internal Medicine, College of Medicine Wonkwang University) ;
  • Yang, Sei Hoon (Department of Internal Medicine, College of Medicine Wonkwang University) ;
  • Cho, Kwang Ho (Department of Neurology, College of Medicine Wonkwang University) ;
  • Jeong, Eun Taik (Department of Internal Medicine, College of Medicine Wonkwang University)
  • 김소영 (원광대학교 의과대학 내과학교실) ;
  • 오효정 (원광대학교 의과대학 내과학교실) ;
  • 황기은 (원광대학교 의과대학 내과학교실) ;
  • 정종훈 (원광대학교 의과대학 내과학교실) ;
  • 김학렬 (원광대학교 의과대학 내과학교실) ;
  • 양세훈 (원광대학교 의과대학 내과학교실) ;
  • 조광호 (원광대학교 의과대학 신경과학교실) ;
  • 정은택 (원광대학교 의과대학 내과학교실)
  • Received : 2005.06.09
  • Accepted : 2005.08.22
  • Published : 2005.10.30
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Abstract

Lambert-Eaton myasthenic syndrome (LEMS), a rare autoimmune neurological syndrome, is caused by defects in the secretion of acetylcholine from the presynaptic membrane, and is associated with the destruction of voltage gated calcium channels (VGCC) in the neuromuscular junction. LEMS can be confirmed by repetitive nerve stimulation and by the clinical symptoms, which are characterized by proximal muscle weakness in the lower extremities, decreased deep tendon reflexes and autonomic dysfunctions. In about 60% of patients with this disorder, underlying cancer-small cell lung cancer may be detected. Clinical symptoms may precede the diagnosis of malignancy, with the early diagnosis and treatment of the underlying malignancy being possible through the diagnosis of LEMS. A case of LEMS, with positive VGCC antibodies, in a 48-year-old man, which improved after chemotherapy of the underlying small cell lung cancer, is reported.

저자들은 점점 진행하는 하지무력증을 주소로 내원한 48세 남자에서 전기생리검사를 시행하여 VGCC 양성인 LEMS를 진단하였고, 동반한 소세포폐암을 진단하여 항암요법을 시행하였고 완치 판정을 받은 후 특별한 치료 없이도 LEMS의 임상증상과 전기생리검사에서 호전을 보인 1예를 경험하였기에 이를 보고하는 바이다.

Keywords

References

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