Macromolecular Research

  • 제13권1호
  • /
  • Pages.54-61
  • /
  • 2005
  • /
  • 1598-5032(pISSN)
  • /
  • 2092-7673(eISSN)
한국고분자학회 (The Polymer Society of Korea)
권호 표지

Release of Calcein from Temperature-Sensitive Liposomes in a Poly(N-isopropylacrylamide) Hydrogel

  • Han Hee Dong (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Kim Tae Woo (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Shin Byung Cheol (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Choi Ho Suk (Department of Chemical Engineering, Chungnam National University)
  • 발행 : 2005.02.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

We prepared temperature-sensitive liposomes (TS-liposomes) modified with a thermo sensitive polymer, such as poly(N-isopropylacrylamide) (PNIPAAm), to increase the degree of drug release from liposomes at the hyperthermic temperature. A PNIPAAm hydrogel containing TS-Iiposomes was also prepared to obtain a hydrogel complex at body temperature. In addition, a depot system for local drug delivery using the polymer hydrogel was developed to enhance therapeutic efficacy and prevent severe side effects in the whole body. The PNIPAAm-mod­ified TS-liposome was fixed into the PNIPAAm hydrogel having a high temperature-sensitivity. The release behavior of calcein, a model drug, from TS-liposomes in the PNIPAAm hydrogel was then initiated by external hyperthermia; the results indicated that sustained release as a function of temperature and time was caused by the thermosensitivity of the liposome surface and diffusion of the drug into the PNIPAAm hydrogel. Our results indicated that TS-liposomes in a PNIPAAm hydrogel represented a plausible system for local drug delivery.

키워드

참고문헌

  1. K. Kono, Adv. Drug. Deliv. Rev., 53, 307 (2001) https://doi.org/10.1016/S0169-409X(01)00236-8
  2. D. Needham and M. W. Dewhirst, Adv. Drug. Deliv. Rev., 53, 285 (2001) https://doi.org/10.1016/S0169-409X(01)00236-8
  3. G. Kong, G. Anyarambhatla, W. P. Petros, R. D. Braun, O. M. Colvin, D. Needham, and M. W. Dewhirst, Cancer Res., 60, 6950 (2000)
  4. O. Ishida, K. Maruyama, H. Yanagie, M. Eriguchi, and M. Iwastru, Jpn. J. Cancer Res., 91, 118 (2000) https://doi.org/10.1111/j.1349-7006.2000.tb00868.x
  5. D. E. Mayer, B. C. Shin, G. A. Kong, M. W. Dewhirst, and A. Chilkoti, J. Control. Release, 74, 213 (2001) https://doi.org/10.1016/S0168-3659(01)00305-4
  6. J. W. Lee, D. S. Lee, and S. W. Kim, Macromol. Res., 11, 189 (2003) https://doi.org/10.1007/BF03218351
  7. S. B. Lee, S. M. Seo, Y. M. Lim, S. K. Cho, Y. M. Lee, and Y. C. Nho, Macromol. Res., 12, 269 (2004) https://doi.org/10.1007/BF03218399
  8. K. H. Kim and Y. J. Shin, Polymer(Korea), 18, 412 (1994)
  9. Y. S. Park, H. D. Han, S. U. Hong, S. S. Kim, and B. C. Shin, Polymer(Korea), 28, 59 (2004)
  10. B. C. Shin, S. S. Kim, J. K. Ko, J. Jegal, and B. M. Lee, Eur. Polym. J., 39, 579 (2003) https://doi.org/10.1016/S0014-3057(02)00291-4
  11. L. H. Tung, Fractionation of Synthetic Polymers, Marcel Dekker, New York, 1977, p. 103
  12. K. Kono, R. NAakai, K. Morimoto, and T. Takagishi, Biochim. Biophys. Acta, 1416, 239 (1999) https://doi.org/10.1016/S0005-2736(98)00226-0
  13. D. Needham, G. Anyarambhatla, G. Kong, and M. W. Dewhirst, Cancer Res., 60, 1197 (2000)
  14. H. Hayashi, K. Kono, and T. Takagishi, Bioconjugate Chem., 10, 412 (1999) https://doi.org/10.1021/bc980111b
  15. L. D. Mayer, M. J. Hope, P. R. Cullis, and A. S. Janoff, Biochim. Biophys. Acta, 817, 193 (1985) https://doi.org/10.1016/0005-2736(85)90084-7
  16. M. J. Hope, M. B. Bally, G. Webb, and P. R. Cullis, Biochim. Biophys. Acta, 812, 55 (1985) https://doi.org/10.1016/0005-2736(85)90521-8
  17. O. Lopez, A. de la Maza, L. Coderch, C. Lopez-Iglesias, E. Wehrli, and J. L. Parra, FEBS Lett., 426, 314 (1998) https://doi.org/10.1016/S0014-5793(98)00363-9
  18. H. Hayashi, K. Kono, and T. Takagishi, Biochem. Biophys. Acta, 1280, 127 (1996) https://doi.org/10.1016/0005-2736(95)00273-1
  19. J. C. Leroux, E. Garrec, D. L. Hong, and D. C. Drummond, J. Control. Release, 72, 71 (2001) https://doi.org/10.1016/S0168-3659(01)00257-7
  20. H. Ringsdorf, J. Venzmer, and F. M. Winnik, Chem. Int. Ed. Engl., 30, 315 (1991) https://doi.org/10.1002/anie.199109911
  21. H. Ringsdorf, E. Sackmann, J. Simon, and F. M. Winnik, Biochim. Biophys. Acta, 1153, 335 (1993) https://doi.org/10.1016/0005-2736(93)90424-X
  22. G. T. Hermanson, Bioconjugate Techniques, Academic Press, San Diego, 1996, pp 305-307
  23. A. Polozova, A. Yamazaki, J. L. Brash, and F. M. Winnik, Colloid Surf. A Physicochem. Eng. Aspects, 147, 17 (1999) https://doi.org/10.1016/S0927-7757(98)00745-6
  24. R. Yoshida, K. Uchida, Y. Kaneko, K. Sakai, A. Kikuchi, Y. Sakurai, and T. Okano, Nature, 374, 240 (1995) https://doi.org/10.1038/374240a0
  25. F. Suisha, N. Kawasaki, S. Miyazaki, M. Shirakawa, K. Yamatoya, M. Sasaki, and D. Attwood, Int. J. Pharm., 172, 27 (1998) https://doi.org/10.1016/S0378-5173(98)00157-4
  26. A. Paavola, I. Kilpelainen, J. Yliruusi, and P. Rosenberg, Int. J. Pharm., 199, 85 (2000) https://doi.org/10.1016/S0378-5173(00)00376-8