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The Pharmaceutical Society of Korea (대한약학회)
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Bone Loss Preventing Effect of Sophorae Fructus On Ovariectomized Rats

  • Published : 2005.01.01
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Abstract

The preventive effects of Sophorae Fructus extracts (I: hot water extract and II: combination product using I) on bone loss in ovariectomized (OVX) rats were investigated. Sophorae Fructus extracts were orally administrated to OVX rats for 9 weeks. Ovariectomy caused the increase of body weight and deoxypyridinoline (Dpd: bone resorption marker) and decrease of calcium (Ca: bone formation marker) level in serum. Dpd level were significantly decreased and Ca levels were elevated at 9 weeks in Sophorae Fructus extracts administered groups after ovariectomy at a dose of 0.556 g/kg/day compared with control group. In administered groups, trabecular bone area (TBA) in the tibia and lumbar were also increased compared with control group in histomorphological analysis. The preventive or treatment effects of Sophorae Fructus extracts on bone loss in OVX rats appears to be due to suppression of bone turnover.

Keywords

References

  1. Akhmedkhodzhaeva, N. M., Svechnikova, A. N., Bandyukova, V. A., and Kambarova, D. M., Determination of flavones in Sophora japonica fruits. Farmatsiya, 35, 60-61 (1986)
  2. Balbaa, S. I., Zaki, A., Y., and Eln Shamy, A. M., Qualitative and quantitative study of the flavonoid content of the different organs of Sophora japonica at different stages of development. Planta Medica, 25, 325-330 (1974) https://doi.org/10.1055/s-0028-1097951
  3. Belcher, S. M. and Zasrnovszky, A., Estogenic actions in the brain: estrogen, phytoestrogen, and rapid intracellular mechanisms. J. Pharmacol. Exp. Ther., 299, 408-414 (2001)
  4. Bhathena, S. M. and Velasquez, M. T., Beneficial role of dietary phytoestrogens in obesity and diabetes. AM. J. Clin. Nutr., 76, 1191-1201 (2002)
  5. Eastell, R., Colwell, A., Hampton, L., and Reeve, J., Biochemical markers of bone resorption compared with estimates of bone resorption from radiotracer kinetic studies in osteoporosis. J. Bone Miner. Res., 12, 59-65 (1997) https://doi.org/10.1359/jbmr.1997.12.1.59
  6. Garnero, P. and Delmas, P. D., New developments in biochemical markers for osteoporosis. Calcified tissue international, 59, S2-9, (1996) https://doi.org/10.1007/s002239900168
  7. Genant, H. K., Bay link, D. J., and Gallagher, J. C., Estrogens in the prevention of osteoporosis in post menopausal women. American Journal of Obsteterics and Gynaecology, 161, 1842-1846 (1998)
  8. Glazier, M. G. and Bowman, M. A., A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch. Intern. Med., 161, 1161- 1172 (2001) https://doi.org/10.1001/archinte.161.9.1161
  9. Gruber, H. E., Ivey, J. L., Baylink, D. L., Mathews, M., Nelp, W. B., Sison, K., and Chestnut, C. H., Lomg-term calcitonin therapy in postmenopaual osteoporosis. Metabolism, 33, 295-303 (1984) https://doi.org/10.1016/0026-0495(84)90187-2
  10. Han, B. H., Takeatsu, K., Paul, P. H. But, Guo, J.-X., and Sung, C. K., International Collation of Traditional and Folk Medicine: Northeast Asia-Part I, World Scientific Publishing Co., Singapore, p.p. 68-69 (1996)
  11. Hesley, R. P., Shepard, K. A., Henkins, D. K., and Riggs, B. L., Monitoring estrogen replacement therapy and identifying rapid bone losers with an immunoassay for deoxypyridinoline. Osteoporosis int., 8, 159-164 (1998) https://doi.org/10.1007/BF02672513
  12. Kariyone, T., Ishimasa, S., and Shiomi, T., Triterpenoids. VIII. Triterpenoids contained in Sophora japonica. Yakugaku Zasshi., 76, 1210-1211 (1956)
  13. Kim, H. J., Kim, M. G., Shim, J. G., Yeom, S. H., and Lee, M. W., Quantitative Determination of Isoflavonoids and Flavonoids from Sophorae Fructus. Chung-Ang Journal of Pharmacal Sciences, 18, 37-43 (2004)
  14. Kim, T. W., The Woody Plants of Korea in Color, Kyo-Hak Publishing Co., Seoul, Korea, p. 399 (1995)
  15. Kimura, M. and Yamada, H., Interaction in the antibacterial activity of flavonoids from Sophora japonica L. to Propionibacterium. Yakugaku zasshi., 104, 340-346 (1984)
  16. Omi, N. and Ezawa, I., The effect of ovariectomy on bone metabolism in rats. Bone, 17, 163S-168S (1995)
  17. Riggs, B. L., Overview of osteoporosis. West J. Med., 154, 63- 77 (1991)
  18. Riley, J. P., The use of continuous extraction for the removal of interfering elements in the determination of calcium and magnesium. Analytica Chimica Acta, 21, 317-323 (1959 ) https://doi.org/10.1016/0003-2670(59)80191-4
  19. Setchell, K. D. R., Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. AM. J. Clin. Nutr., 68, 1333S-1346S (1998)
  20. Seyedin, S. M. and Rosen, D. M., Matrix Proteins of the Skeleton. Curr. Opin. Cell Biol., 2, 914-919 (1990) https://doi.org/10.1016/0955-0674(90)90092-S
  21. Stark, A. and Madar, Z., Phytoestrogens: a review of recent findings. J. Pediatr. Endocrinol. Metab., 15, 561-572 (2002)
  22. Takahashi, M., Ishimasa, S., and Koyama, Y., Components of Sophora japonica. IV. Optical rotary dispersion curve of the derivative of sophoradiol. Yakugaku Zasshi., 80, 698-699 (1960)
  23. Van Staveren, W. A., de Groot, L. C., Blanco, Y. H., and Van der Wilen, R. P., Assessing diets of elderly people: problems and approaches. Am. J. Clin. Nutr., 59, 2215-2235 (1999)
  24. Wang, L.-Q., Mammalian phytoestrogens: enterodiol and enterolactone. J. Chromatoar., B 777, 289-309 (2002)