한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제22권2호
  • /
  • Pages.182-190
  • /
  • 2005
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  • 1225-9098(pISSN)
  • /
  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
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In Vitro에서 광증감제에 의한 광학적 영향에 관한 연구

A Study on the Optical Influence by Photosensitizer in Vitro

  • 김기준 (대진대학교 공과대학 화학공학과) ;
  • 성기천 (대진대학교 공과대학 화학공학과)
  • Kim, Ki-Jun (Dept. of Chemical Engineering, Dae-Jin University) ;
  • Sung, Ki-Chun (Dept. of Chemical Engineering, Dae-Jin University)
  • 발행 : 2005.06.30
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초록

The propagation of light radiation within tissues is an important problem that confronts the dosimetry of therapeutic laser delivery and the development of diagnostic spectroscopy. In the clinical application of photodynamic therapy(PDT) and in photobiology, the photon deposition within a tissue determines the spatial distribution of photochemical reactions. Scattered light is measured as a function of the distance (r) between the axis of the incident beam and the detection spot. Consequently, knowledge of the photosensitizer(Chlorophyll-a) function that characterizes a phantom is important. To obtain the results of scattering coefficients(${\mu}s$) of a turbid material from diffusion described by experimental approach. It was measured the energy fluency of photon radiation at the position of penetration depth. From fluorescence experimental method obtained the analytical expression for the scattered light as the values of $(I\;/I_o)_{wavelength}$ vs the distance between the center of the incident beam and optical fiber in terms of the condition of "in situ spectroscopy(optically thick)" and real time by fluorometric measurements.

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