Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Monoamine Oxidase Inhibitory Naphthoquinones from the Roots of Lithospermum erythrorhizon

  • Choi Woo Hoi (College of Pharmacy, Chungbuk National University) ;
  • Hong Seong Su (College of Pharmacy, Chungbuk National University) ;
  • Lee Seon A (College of Pharmacy, Chungbuk National University) ;
  • Han Xiang Hua (College of Pharmacy, Chungbuk National University) ;
  • Lee Kyong Soon (College of Pharmacy, Chungbuk National University) ;
  • Lee Myung Koo (College of Pharmacy, Chungbuk National University, Research Center for Biore-source and Health, Chungbuk National University) ;
  • Hwang Bang Yeon (College of Pharmacy, Chungbuk National University) ;
  • Ro Jai Seup (College of Pharmacy, Chungbuk National University)
  • Published : 2005.04.01
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Abstract

Activity-guided fractionation of a hexane-soluble extract of the roots of Lithospermum erythrorhizon, using a mouse brain monoamine oxidase (MAO) inhibition assay, led to the isolation of two known naphthoquinones, acetylshikonin and shikonin, and a furylhydroquinone, shikonofuran E. These compounds were shown to inhibit MAO with $IC_{50}$ values of 10.0, 13.3, and $59.1 {\mu}M$, respectively. Although no specificity for MAO-A and MAO-B was shown by acetylshikonin and shikonin, a Lineweaver-Burk plot analysis indicated that the inhibition was competitive for both MAO-A and MAO-B activity.

Keywords

References

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