Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Antiinflammatory Constituents from the Roots of Smilax bockii warb.

  • Xu Jing (Research Department of Natural Medicine, Shenyang Pharmaceutical University) ;
  • Li Xian (Research Department of Natural Medicine, Shenyang Pharmaceutical University) ;
  • Zhang Peng (Research Department of Natural Medicine, Shenyang Pharmaceutical University) ;
  • Li Zhan-Lin (Research Department of Natural Medicine, Shenyang Pharmaceutical University) ;
  • Wang Yi (Research Department of Natural Medicine, Shenyang Pharmaceutical University)
  • Published : 2005.04.01
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Abstract

From $70\%$ ethanol extract of the roots of Smilax bockii warb., seven flavonoids, kaempferol (1), $kaempferol-7-O-\beta-D-glucopyranoside$ (2), quercetin (3), isorhamnetin (4), (+)-dihydro­kaempferol (5), engeletin (6), isoengeletin (7), and $n-butyl-\beta-D-fructopyranoside$ (8), caffeic acid n-butyl ester (9) were isolated and identified by means of chemical and spectroscopic. Compounds 2, 4, and 6-9 were isolated for the first time from the roots of S. bockii and compounds 2, 8, and 9 were firstly isolated from the genus Smilax. In addition, using the SEAP (Secreted alkaline phosphatase) assay system, we investigated the in vitro anti-inflammatory activity of the $70\%$ ethanol extract of the roots of S. bockii, which showed moderate activity in inhibiting $TNF-\alpha-induced NF-{\kappa}B$ activation with an $IC_{50}$ value of $166.6 {\mu}g/mL$.

Keywords

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