Archives of Pharmacal Research

  • 제28권4호
  • /
  • Pages.395-399
  • /
  • 2005
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Antiinflammatory Constituents from the Roots of Smilax bockii warb.

  • Xu Jing (Research Department of Natural Medicine, Shenyang Pharmaceutical University) ;
  • Li Xian (Research Department of Natural Medicine, Shenyang Pharmaceutical University) ;
  • Zhang Peng (Research Department of Natural Medicine, Shenyang Pharmaceutical University) ;
  • Li Zhan-Lin (Research Department of Natural Medicine, Shenyang Pharmaceutical University) ;
  • Wang Yi (Research Department of Natural Medicine, Shenyang Pharmaceutical University)
  • 발행 : 2005.04.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

From $70\%$ ethanol extract of the roots of Smilax bockii warb., seven flavonoids, kaempferol (1), $kaempferol-7-O-\beta-D-glucopyranoside$ (2), quercetin (3), isorhamnetin (4), (+)-dihydro­kaempferol (5), engeletin (6), isoengeletin (7), and $n-butyl-\beta-D-fructopyranoside$ (8), caffeic acid n-butyl ester (9) were isolated and identified by means of chemical and spectroscopic. Compounds 2, 4, and 6-9 were isolated for the first time from the roots of S. bockii and compounds 2, 8, and 9 were firstly isolated from the genus Smilax. In addition, using the SEAP (Secreted alkaline phosphatase) assay system, we investigated the in vitro anti-inflammatory activity of the $70\%$ ethanol extract of the roots of S. bockii, which showed moderate activity in inhibiting $TNF-\alpha-induced NF-{\kappa}B$ activation with an $IC_{50}$ value of $166.6 {\mu}g/mL$.

키워드

참고문헌

  1. Ding, L. S., Liang, Q. L., and Teng, Y. F., Flavonoids from Hovenia dulcis Thunb. Acta Pharmaceutica Sinica, 32, 600- 602 (1997)
  2. Dulce, H. S., Massayoshi, Y., and Massuo J., K., Flavonoids from Iryanthera Sagotiana. Phytochemistry, 46, 579-582 (1997) https://doi.org/10.1016/S0031-9422(97)00306-3
  3. Haraguchi, Y., Yagi, A., and Koda, A., A specific inhibitor of IgEantibody formation: $n-butyl-\alpha-D-fructopyranoside$. J. Med. Chem., 25, 149 (1982) https://doi.org/10.1021/jm00354a021
  4. Hu, L. H. and Chen, Z. L., Structure elucidation of a new npentyl fructofuranoside in Dendranthema morifolium (Ramat.) Tzvel. Acta Botanica Sinica, 39, 181-184 (1997)
  5. Koo, T., Lee, J., Park, Y., Hong, Y., Kim, H., Kim, K. and Lee, J., A Sesquiterpene Lactone, Costunolide, from Magnolia grandiflora Inhibits $NF-\kappaB$ by Targeting $I\kappaB$ Phosphorylation. Planta Medica, 67, 103-107 (2001) https://doi.org/10.1055/s-2001-11503
  6. Li, N., Li, X., Wang, J. H., and Wang, N., Studies on chemical constituents of the total flavanoids from Comptosorus sibiricus Rupr.(1). Journal of Shenyang Pharmaceutical University, 21, 105-107 (2004)
  7. Markham, K. R., Ternai, B., and Stanley, R., Carbon-13 NMR studies of flavonoids-III. Naturally occurring flavonoid glycosides and their acylated derivatives. Tetrahedron, 34, 1389-1397 (1978) https://doi.org/10.1016/0040-4020(78)88336-7
  8. Masanori, S., Youichiro, N., Yasunari, Y., Chikara, F., and Kazumasa, Y., Inhibitory activities and inhibition specidicities of caffeic acid derivatives and related compounds toward 5- lipoxygenase. Chem. Pharm. Bull., 37, 1039-1043 (1989) https://doi.org/10.1248/cpb.37.1039
  9. Qu, G. R., Liu, J., Li, X. X., Wang, S. X., Wu, L. J., and Li, X., Study on flavonoids of Sonchus arvensis L. Chinese Traditional and Herbal Drugs, 26, 233-235 (1995)
  10. Yue,J. M., Chen, S. N., Yang, S. P., Fan, C. Q., Lin, Z. W., and Sun, H. D., Chemcal components from Craniotome furcata. Acta Botanica Sinica, 43, 1199-1201 (2001)
  11. Zhang, C. Z., Xu, X. Z., and Li, C., Fructosides from Cynomorium Songaricum. Phytochemistry, 41, 975 (1996) https://doi.org/10.1016/0031-9422(95)00705-9