Synthesis of Polymeric Thiazolidinediones and L-Ascorbic Acid Towards the Development of Insulin-Sensitizer

  • Lee Sun Mi (College of Pharmacy, Sookmyung Women's University) ;
  • Jeon Raok (College of Pharmacy, Sookmyung Women's University)
  • 발행 : 2005.04.01

초록

Polymers, containing 5-(4-O-methylacryloylbenzyl)thiazolidine-2,4-dione [MABTZD]; poly (MABTZD), poly(MABTZD-co-AA) and poly(MABTZD-co-AMAA), were prepared, and identified by FT-IR, $^1H-$ and $^{13}C-NMR$ spectra. The MABTZD unit contents in poly(MABTZD-co-AA) and poly(MABZD-co-AMAA) were 11.3 and $27.7 mol\%$, respectively. The number average molecular weights of the polymers, as determined by GPC, ranged from 16,800 to 22,300, and with polydispersity indices of $1.2\sim1.4$.

키워드

참고문헌

  1. Fujiwara, T., Yoshioka, S., Yoshioka, T., Ushiyama, I., and Horikoshi, H., Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats. Diabetes, 37, 1549-1558 (1988) https://doi.org/10.2337/diabetes.37.11.1549
  2. Cantello, B. C. C., Cawthorne, M. A., Cottam, G. P., Duff, P. T., Haigh, D., Hindley, R. M., Lister, C. A., Smith, S. A., and Thurlby, P. L., [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents. J. Med. Chem., 37, 3977-3985 (1994) https://doi.org/10.1021/jm00049a017
  3. Meguro, K. and Fujita, T., Thiazolidinedione derivatives, and their medicinal compositions. EP 0155845 (1985)
  4. Lehman, J. M., Moore, L. B., Smith- Oliver, T. A., Wilkison, W. O., Willson T. M., and Kliewer, S. A., An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem., 270, 12953-12956 (1995) https://doi.org/10.1074/jbc.270.22.12953
  5. Frei, B., Stocker, R., England, L., and Ames, E. N., Plenum Press, New Work, pp 155-164 (1991)
  6. Maxwell, S. R., Thomason, H., Sandler, D., Leguen, C., Baxter, M. A., Thorpe, G. H., Jones, A. F., and Barnett, A. H. Antioxidant status in patients with uncomplicated insulindependent and non-insulin-dependent diabetes mellitus., Eur. J. Clin. Inest., 27, 484-490 (1997) https://doi.org/10.1046/j.1365-2362.1997.1390687.x
  7. Torres, M. D., Canal, J. R., and Perez, C., Oxidative stress in normal and diabetic rats. Physiol. Res. 48, 203-208 (1999)