Synthesis of Polymeric Thiazolidinediones and L-Ascorbic Acid Towards the Development of Insulin-Sensitizer

Polymers, containing 5-(4-O-methylacryloylbenzyl)thiazolidine-2,4-dione [MABTZD]; poly (MABTZD), poly(MABTZD-co-AA) and poly(MABTZD-co-AMAA), were prepared, and identified by FT-IR, $^1H-$ and $^{13}C-NMR$ spectra. The MABTZD unit contents in poly(MABTZD-co-AA) and poly(MABZD-co-AMAA) were 11.3 and $27.7 mol\%$, respectively. The number average molecular weights of the polymers, as determined by GPC, ranged from 16,800 to 22,300, and with polydispersity indices of $1.2\sim1.4$.