Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Oriental Medicinal Drugs on Axonal Regeneration in the Spinal Cord Neurons

  • An Joung-Jo (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • NamGung Uk (Department of Neurophysiology, College of Oriental Medicine, Daejeon University) ;
  • Seo In-Chan (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Kim Yoon-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
  • Published : 2005.12.01
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Abstract

An oriental medicinal drugs Jahageo (JHG, Hominis placenta) were examined to determine its effects on the responsiveness of central nervous system neurons after injury. We found that JHG was involved in neurite outgrowth of DRG sensory axons. JHG treatment also increased expression of axonal growth-associated protein GAP-43 in DRG sensory neurons after sciatic nerve injury and in the injured spinal cord. JHG treatment during the spinal cord injury increased induction levels of cell division cycle 2 (Cdc2) protein in DRG as well as in the spinal cord. Histochemical investigation showed that induced Cdc2 in the injured spinal cord was found in non-neuronal cells. These results suggest that JHG regulates activities of non-neuronal cells such as oligodendrocyte and astrocyte in responses to spinal cord injury and protects neuronal responsiveness after axonal damage.

Keywords

References

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