Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Reproductive Toxicity Study of CONP01, a New Antiarthritic Agent: Developmental Study in Rats

새로운 관절염 치료제 CONP01의 생식독성연구: 랫드 배 · 태자 발생시험

  • 이정숙 ((주)켐온 전임상 연구센터) ;
  • 홍동호 ((주)켐온 전임상 연구센터) ;
  • 김광호 ((주)켐온 전임상 연구센터) ;
  • 장호송 ((주)켐온 전임상 연구센터) ;
  • 길기현 ((주)켐온 전임상 연구센터) ;
  • 한명규 ((주)켐온 전임상 연구센터) ;
  • 양현주 ((주)켐온 전임상 연구센터) ;
  • 배진숙 ((주)켐온 전임상 연구센터) ;
  • 김남두 ((주)켐온 전임상 연구센터) ;
  • 송시환 ((주)켐온 전임상 연구센터)
  • Published : 2005.03.01
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Abstract

A developmental study of CONP01, a new antiarthritic agent, was conducted in Sprague-Dawley rats. Dosage of CONP01 0, 111, 333, and 1000 mg/kg/day were administered to dams orally from day 6 to day 16 of gestation. Two-third of dams per group were subjected to caesarean section on day day 20 of pregnancy for examination of their fetuses, and the remaining one-third of dams per group were allowed to deliver naturally for postnatal examination of their offspring. There was no change in the dams body weights, food consumptions, specific clinical sings and gross findings. There was significant decrease only in the absolute and relative weights of right ovary in 111 mg/kg treatment group, when compared with the vehicle control, whereas other organ weights were not changed. Moreover, no increase in the frequencies of external, visceral and skeletal malformation of fetuses were observed in the treated groups. These results suggest that the oral NOAEL (no observed adverse effect level) of CONP01 may be over 1,000 mg/kg in dams and fetuses of rats.

Keywords

References

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