Effects of Diclofenac, Acetamonophen, Nimesulide and Acetylsalicylic Acid on Mucin Release from Cultured Hamster Tracheal Surface Epthelial Cells

  • HEO Ho Jin (Department of Pharmacology, College of Medicine, Chungnam National University) ;
  • LEE Hyun Jae (Department of Pharmacology, College of Medicine, Chungnam National University) ;
  • YOON Chi Soon (Department of Thoracic Surgery, Chungnam National University Hospital) ;
  • LIM Seung Pyong (Department of Thoracic Surgery, Chungnam National University Hospital) ;
  • SEOK Jeong Ho (Department of Pharmacology, College of Medicine, Chungnam National University) ;
  • LEE Choong Jae (Department of Pharmacology, College of Medicine, Chungnam National University)
  • Published : 2005.12.01

Abstract

In this study, we tried to investigate whether diclofenac, acetaminophen, nimesulide, acetylsalicylic acid and tumor necrosis factor-alpha (TNF-alpha) significantly affect mucin release from cultured airway goblet cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with $^3H$-glucosamine for 24 hr and chased for 30 min or 24 hr in the presence of each agent to assess the effects on $^3H$-mucin release. The results were as follows: (1) TNF-alpha significantly increased mucin release from cultured HTSE cells during 24 hr of treatment period; (2) However, diclofenac, acetaminophen, nimesulide and acetylsalicylic acid did not affect mucin release, during 30 min of treatment period. Basically, this finding suggests that non-steroidal antiinflammatory drugs (NSAIDs) might not function as a mucoregulator in various inflammatory respiratory diseases showing mucus hypersecretion, although further studies are needed.

Keywords

References

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