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Effects of Diclofenac, Acetamonophen, Nimesulide and Acetylsalicylic Acid on Mucin Release from Cultured Hamster Tracheal Surface Epthelial Cells  

HEO Ho Jin (Department of Pharmacology, College of Medicine, Chungnam National University)
LEE Hyun Jae (Department of Pharmacology, College of Medicine, Chungnam National University)
YOON Chi Soon (Department of Thoracic Surgery, Chungnam National University Hospital)
LIM Seung Pyong (Department of Thoracic Surgery, Chungnam National University Hospital)
SEOK Jeong Ho (Department of Pharmacology, College of Medicine, Chungnam National University)
LEE Choong Jae (Department of Pharmacology, College of Medicine, Chungnam National University)
Publication Information
Biomolecules & Therapeutics / v.13, no.4, 2005 , pp. 246-250 More about this Journal
Abstract
In this study, we tried to investigate whether diclofenac, acetaminophen, nimesulide, acetylsalicylic acid and tumor necrosis factor-alpha (TNF-alpha) significantly affect mucin release from cultured airway goblet cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with $^3H$-glucosamine for 24 hr and chased for 30 min or 24 hr in the presence of each agent to assess the effects on $^3H$-mucin release. The results were as follows: (1) TNF-alpha significantly increased mucin release from cultured HTSE cells during 24 hr of treatment period; (2) However, diclofenac, acetaminophen, nimesulide and acetylsalicylic acid did not affect mucin release, during 30 min of treatment period. Basically, this finding suggests that non-steroidal antiinflammatory drugs (NSAIDs) might not function as a mucoregulator in various inflammatory respiratory diseases showing mucus hypersecretion, although further studies are needed.
Keywords
airway; mucin; NSAIDs;
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