Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Serum Insulin, Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 Levels in Obese Adolescents

비만 청소년에서 Insulin, Insulin-like Growth Factor-I, Insulin-like Growth Factor Binding Protein-3에 대한 연구

  • Kwon, Jung Hyun (Department of Pediatrics, College of Medicine, Ewha Womans University) ;
  • Kim, Hyun Jin (Department of Pediatrics, College of Medicine, Ewha Womans University) ;
  • Hong, Young Mi (Department of Pediatrics, College of Medicine, Ewha Womans University)
  • 권정현 (이화여자대학교 의과대학 소아과학교실) ;
  • 김현진 (이화여자대학교 의과대학 소아과학교실) ;
  • 홍영미 (이화여자대학교 의과대학 소아과학교실)
  • Received : 2005.06.22
  • Accepted : 2005.08.08
  • Published : 2005.11.15
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Abstract

Purpose : Childhood Obesity is increasing throughout the world, and it is known to incur many diseases especially in later life such as diabetes and cardiovascular disorders. The purpose of this study was to investigate the association between obesity and insulin, insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3(IGFBP-3) and know if these factors are useful in predicting cardiovascular diseases. Methods : The study group consisted of 64 moderate and severe obese adolescents and the controls were normal adolescents of the same age. body mass index(BMI) was calculated by height and weight; systolic and diastolic blood pressure was measured at resting state. After 10-hour fasting period, blood cholesterol, triglyceride, high density lipoprotein(HDL) cholesterol, low density lipoprotein(LDL) cholesterol, glucose, insulin, free fatty acid, IGF-I and IGFBP-3 were measured. Results : Insulin was significantly higher in the obese adolescent group than the control group(obese group $15.6{\pm}7.0{\mu}IU/mL$, P<0.01). IGF-I was also significantly higher in the obese adolescent group than the control group(obese group $498.1{\pm}122.2ng/mL$, P<0.05). In addition, IGFBP-3 was significantly higher in the obese adolescent group than the control group(obese group $3,777{\pm}4,721ng/mL$, P<0.05). Insulin showed significantly positive correlation with BMI(r=0.3944) and obesity index(r=0.34). IGFBP-3 were significantly correlated with obesity index(r=0.419), diastolic blood pressure (r=0.264) and BMI(r=0.247). Insulin resistance index significantly positive correlation with BMI(r=0.595), blood triglycerid level(r=0.515) and obesity index(r=0.469). Conclusion : Serum insulin, insulin resistance index, IGF-I and IGFBP-3 levels may be useful to predict cardiovascular diseases in adolescent obesity.

목 적 : 소아 비만은 전세계적으로 증가하고 있는 추세이며, 신체적으로나 정신적으로 장애를 일으킨다. 특히 고혈압, 관상동맥질환, 당뇨병 등의 성인병이 문제가 되고 있다. 이에 비만 청소년에서 혈중 인슐린, 인슐린저항지수, 유리 지방산, IGF-I, IGFBP-3를 측정하였고, 심혈관 질환으로 진행할 수 있는 위험인자로 유용한지 알아보기 위해 본 연구를 실시하였다. 방 법 : 64명의 중등도 이상의 비만 청소년를 대상군으로 하였고, 같은 연령의 정상 청소년 20명을 대조군으로 하였다. 신장, 체중을 이용하여 비만도와 체질량지수를 산출하였고, 안정된 상태에서 수축기, 이완기 혈압을 측정하였다. 10시간 이상 금식 후 총 콜레스테롤, 중성지방, HDL 콜레스테롤, LDL 콜레스테롤, AST, ALT, 혈당, 인슐린, 유리지방산, IGF-I, IGFBP-3를 측정하였다. 결 과 : 인슐린은 비만군에서 $15.6{\pm}7.0{\mu}IU/mL$로 정상군보다 유의하게 높았고(P<0.01), 인슐린저항지수도 비만군에서 $64.6{\pm}31.6$으로 정상군보다 유의하게 높았다(P<0.01). IGF-I은 비만군에서 $498.1{\pm}122.2ng/mL$로 정상군보다 유의하게 높았고(P<0.05), IGFBP-3도 비만군에서 $3,777{\pm}4,721ng/mL$로 정상군보다 유의하게 높았다(P<0.05). 인슐린은 체질량지수(r=0.394), 비만도(r=0.304)와 양의 상관관계를 나타냈다. IGFBP-3는 비만도(r=0.419), 이완기 혈압(r=0.264), 체질량지수(r=0.247)와 양의 상관관계를 보였다. 인슐린저항지수는 체질량지수(r=0.595), 혈중 중성지방(r=0.515), 비만도(0.469)와 양의 상관관계를 나타냈다. 결 론 : 비만 청소년에서 혈중 인슐린, 인슐린저항지수, IGF-I, IGFBP-3가 증가하였다. 청소년 비만에서 이들 검사는 심혈관질환으로의 진행을 예측하는데 유용하리라 생각한다.

Keywords

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