Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Phenolic Constituents with Inhibitory Activity against NFAT Transcription from Desmos chinensis

  • Kiem Phan Van (Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology) ;
  • Minh Chau Van (Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology) ;
  • Huang Hoang Thanh (Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology) ;
  • Lee Jung Joon (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee Im Seon (College of Pharmacy, Chungnam National University) ;
  • Kim Young Ho (College of Pharmacy, Chungnam National University)
  • Published : 2005.12.01
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Abstract

Six phenolic constituents, 2-methoxybenzyl benzoate (1), negletein (2), 2',3'-dihydroxy-4',6'­dimethoxydihydrochalcone (3), 5,6-dihydroxy-7-methoxy-dihydroflavone (4), astilbin (5), and quercitrin (6) were isolated from the methanol extract of the dried leaves of Desmos chinensis. Their structures were elucidated from spectral and chemical data. Of these constituents, compounds 2 ($IC_{50}$: 3.89 $\pm$ 0.39 $\mu$M) and 3 ($IC_{50}$: 9.77 $\pm$ 0.26 $\mu$M) exhibited potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor, and compound 1 ($IC_{50}$: 28.4 $\pm$ 2.62 $\mu$M) exhibited moderate inhibitory activity.

Keywords

References

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