Archives of Pharmacal Research

  • 제28권12호
  • /
  • Pages.1324-1327
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  • 2005
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Monoamine Oxidase Inhibitory Constituents from the Fruits of Cudrania tricuspidata

  • Han Xiang Hua (College of Pharmacy, Chungbuk National University) ;
  • Hong Seong Su (College of Pharmacy, Chungbuk National University) ;
  • Hwang Ji Sang (College of Pharmacy, Chungbuk National University) ;
  • Jeong Seon Hwa (College of Pharmacy, Chungbuk National University) ;
  • Hwang Ji Hye (College of Pharmacy, Chungbuk National University) ;
  • Lee Min Hee (College of Pharmacy, Chungbuk National University) ;
  • Lee Myung Koo (College of Pharmacy, Chungbuk National University, Research Center for Bioresource and Health, Chungbuk National University) ;
  • Lee Dongho (Korea Research Institute of Bioscience and Biotechnology) ;
  • Ro Jai Seup (College of Pharmacy, Chungbuk National University) ;
  • Hwang Bang Yeon (College of Pharmacy, Chungbuk National University)
  • 발행 : 2005.12.01
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초록

A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4'-O-methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with $IC_{50}$ values of 19.4, 23.9, and 25.8 $\mu$M, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B ($IC_{50}$ 0.8 $\mu$M) than MAO-A ($IC_{50}$ >800 $\mu$M). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

키워드

참고문헌

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