Archives of Pharmacal Research

  • 제28권11호
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  • Pages.1251-1256
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  • 2005
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Cytoprotective Effect of Green Tea Extract and Quercetin against Hydrogen Peroxide-Induced Oxidative Stress

  • Jeong Yun-Mi (Department of Dermatology, Seoul National University College of Medicine) ;
  • Choi Yeong-Gon (Department of Dermatology, Seoul National University College of Medicine) ;
  • Kim Dong-Seok (Department of Dermatology, Seoul National University College of Medicine) ;
  • Park Seo-Hyoung (Department of Dermatology, Seoul National University College of Medicine) ;
  • Yoon Jin-A (Department of Dermatology, Seoul National University College of Medicine) ;
  • Kwon Sun-Bang (Welskin Co. Ltd.) ;
  • Park Eun-Sang (Department of Dermatology, Seoul National University College of Medicine) ;
  • Park Kyoung-Chan (Department of Dermatology, Seoul National University College of Medicine)
  • 발행 : 2005.11.01
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초록

In this study, we evaluated the cytoprotective effects of antioxidative substances in hydrogen peroxide ($H_{2}O_{2}$) treated Mel-Ab melanocytes. Tested substances include selenium, quercetin, green tea (GT) extract, and several vitamins (ascorbic acid, Trolox, and folic acid). Of these, both quercetin and GT extract were found to have strong cytoprotective effects on $H_{2}O_{2}$­induced cell death. We also examined additive effects, but no combination of two of any of the above substances was found to act synergistically against oxidative damage in Mel-Ab cells. Nevertheless, a multi-combination of GT extract, quercetin, and folic acid appeared to prevent cellular damage in a synergistic manner, which suggests that combinations of antioxidants may be of importance, and that co-treatment with antioxidants offers a possible means of treating vitiligo, which is known to be related to melanocyte oxidative stress.

키워드

참고문헌

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