약학회지 (YAKHAK HOEJI)

  • 제49권6호
  • /
  • Pages.471-476
  • /
  • 2005
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

옻나무 플라보노이드가 수컷 백서의 성행동에 미치는 영향

The Effect of Flavonoid Fraction Extracted from Rhus verniciflua Stokes on Sexual Behavior in SD Male Rats

  • 발행 : 2005.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Rhus verniciflua Stokes (RVS) has been used as a food supplement and a traditional herbal medicine for a men's sexual enhancement. In this study, we prepared a flavonoid fraction (RWE) from a hot water extract of RVS and its influence on sexual behavior was studied in male rats which were orally administered varying doses of RWE for 2 weeks. All doses of RWE stimulated sexual behavior in male rats such as reducing mounting latency and enhancing mount frequencies. However, intermission numbers were not changed and none of group can observe the ejaculation during behavioral testing time 5 min. Testosterone levels were Increased about 0$\∼$53$\%$ and 92$\∼$164$\%$ by the treatment of RWE for 1 and 2 weeks, respectively. However, estrogen levels in male rats tended to decrease in a dose dependent manner of RWE. At the dose of RWE 200 mg/kg, estrogen level was reduced to 77.5$\%$ and 70.3$\%$ of control after 1 and 2 weeks treatment. These findings suggest that the Rhus flavonoid fraction can stimulate the androgen-dependent male sexual behavior and it can be applied to the material of functional food for enhancing the sexual function.

키워드

참고문헌

  1. Gray, A., Feldman, H. A., McKinlay, J. B. and Longcope, C. : Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J. Clin. Endoerinol. Metab. 73, 1016 (1991) https://doi.org/10.1210/jcem-73-5-1016
  2. Gooren, L. J. : The benefits and risks of androgen therapy in the aging male: prostate disease, lipids and vascular factors. In: Wren, B. G., editor. Progress in the management of the menopause. Parthenon Publishing, 340 (1997)
  3. 김세종 : 남성갱년기와 호르몬 보충요법. 대한남성과학회지 22, 45 (2004)
  4. Hong, D. H., Han, S. B., Lee, C. W., Park, S. H., Jeon, Y. J., Kim, M. J., Kwak, S. S. and Kim, H. W. : Cytotoxicity of urushiols isolated from sap of Korean lacquer tree (Rhus vernicijlua Stokes). Arch. Pharm. Res. 22, 638 (1999) https://doi.org/10.1007/BF02975339
  5. Lee, J. C., Jung, H. Y. and Lim, K. T. : Effects of Rhus verniciflua Stokes (RVS) on the plasma level of cholesterol and tumor growth in mouse. J. Toxicol. Public Health 15, 169, (1999)
  6. Kitts, D. D. and Lim, K. T. : Antitumorigenic and cytotoxic properties of an ethanol extract derived from Rhus verniciflua Stokes (RVS). J. Toxicol. Environ. Health A. 64, 357, (2001) https://doi.org/10.1080/15287390152539451
  7. Kim, I. W., Shin, D. H. and Baek, N. I. : Identification of antioxidantive components from ethanol extract of Rhus verniciflua Stokes. Korean J. Food Sci. Technol. 31, 1654 (1999)
  8. Lee, J. C., Lim, K. T. and Jang, Y. S. : Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. Biochim. Biophys. Acta 1570, 181 (2002) https://doi.org/10.1016/S0304-4165(02)00196-4
  9. Lim, K. T., Hu, C. and Kitts, D. D. : Antioxidant activity of a Rhus verniciflua Stokes ethanol extract. Food Chem Toxicol. 39, 229, (2001) https://doi.org/10.1016/S0278-6915(00)00110-1
  10. Son, Y. O., Lee, K. Y., Lee, J. C., Jang, H. S., Kim, J. G., Jeon, Y. M. and Jang, Y. S. ; Selective antiproliferative and apoptotic effects of tlavonoids purified from Rhus verniciflua Stokes on normal versus transformed hepatic cell lines. Toxicol Lett. 155, 115 (2005) https://doi.org/10.1016/j.toxlet.2004.09.003
  11. 성환후, 최선호, 장유빈, 민관식, 우제현, 장원경, 정남철, 나천수, 정일정 : 옻나무 유래 flavonoid 처리가 흰쥐 leydig 세포의 체외배양에서testosterone 분비에 미치는 영향, Korean J. Animal Reprod. 25, 125 (2001)
  12. Waynforth, H. B. and FleckneII P.A. : Experimental and surgical techniques in the Rat, Academic Press (1992)
  13. 손환철, 변석수, 박은찬, 조규선, 조문기, 김수웅, 김현희, 백재승, 이종옥 : 서울지역 40세 이상 남성의 성기능장애의 유병률: 설문지에 의한 역학조사. 대한비뇨기과학회지 43, 52 (2002)
  14. Beach, F. A., Conovitz, M. W., Goldstein, A.C. and Steinberg, F. : Experimental inhibition and restoration of mating behavior in male rats. J. Genet. Psychol. 89, 165 (1956) https://doi.org/10.1080/00221325.1956.10534212
  15. Zanoli, P., Benelli, A., Rivasi, M., Baraldi, C., Vezzalini, F. and Baraldi, M. : Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats. Int. J. Impot. Res. 15, 450 (2003) https://doi.org/10.1038/sj.ijir.3901051
  16. Ren, J. C., Banan, A., Keshavarzian, A., Zhu, Q., Lapaglia, N., McNulty, J., Emanuele, N. V. and Emanuele, M. A.: Exposure to ethanol induces oxidative damage in the pituitary gland. Alcohol. 35, 91 (2005) https://doi.org/10.1016/j.alcohol.2005.03.005
  17. Paick, J. S. and Lee, S. W. : The neural mechanism of apomorphine-induced erection: an experimental study by comparison with electrostimulation-induced erection in the rat model. J. Urol. 152, 2125 (1994)
  18. 이성원, 백제승 : Apomorphine-유발 음경발기 백서 모델에서 남성호르몬 환경변화가 발기 및 대뇌 dopamine 수용체에 미치는 영향. 대한비뇨회지 35, 458 (1994)
  19. Sato, Y., Shibuya, A., Adachi, H., Shinichi, H., Taiji, T. and Paick, J. S. : Effects of long-term exogenous testosterone replacement in aged male rats on sexual behavior and dopaminergic neurotransmission. J. Ural. 155, 619A (1996)
  20. Keast, J. R. : The autonomic nerve supply of male sex organs-an important target of circulating androgens. Behav. Brain. Res. 105, 81 (1999) https://doi.org/10.1016/S0166-4328(99)00084-4
  21. Manzo, J., Cruz, M. R., Hernandez, M. E., Pacheco, P. and Sachs, B. D. : Regulation of noncontact erection in rats by gonadal steroids. Horm Behav. 35, 264 (1999) https://doi.org/10.1006/hbeh.1999.1519
  22. Samoszuk, M., Tan, J. and Chorn, G. : The chalcone butein from Rhus verniciflua Stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts. BMC Complement Altern Med. 5, 5 (2005) https://doi.org/10.1186/1472-6882-5-5
  23. Pouget, C., Fagnere, C., Basly, J. P., Habrioux, G. and Chulia, A. J. : Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition. Bioorg Med. Chem. Lett. 12, 2859 (2002) https://doi.org/10.1016/S0960-894X(02)00565-6
  24. Brueggemeier, R. W., Hackett, J. C. and Diaz-Cruz, E. S. : Aromatase inhibitors in the treatment of breast cancer. Endocr Rev. 26, 331 (2005) https://doi.org/10.1210/er.2004-0015