Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Protective Effects of Welsh Onion (Allium fistulosum L.) on Drug-induced Hepatotoxicity in Rats

랫드의 약물성 간장 장해에 대한 대파의 보호 효과

  • Published : 2005.11.01
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Abstract

The aim of this study was to evaluate the effects of Welsh onion administration on $CCl_4$-induced hepatic injury in rats. The increasing rate of the body and organ weight was not significantly different by the ad-ministration of the Welsh onion. Welsh onion (2, 4, $10\%$ w/w) was given for 4 weeks with the injections of $CCl_4$. Total serum lipid was significantly decreased in all treatment groups compared to $CCl_4$ only treatment group (p<0.05). The Welsh onion from winter season was more protective effect by lowering the serum levels of transminase (SGOT and SGPT) compared with others, the levels of transminase - phosphatase (ALP) in serum. The Welsh onion from winter at a dose of $4\%,\;10\%$ (w/w) showed significantly hepatoprotective activity which was comparable to that $CCl_4$-induced hepatic damage. Histological evaluation showed that Welsh onion partially prevented $CCl_4$-induced inflammation, necrosis and vacuolation. Pretreatment of Welsh onion reduced extent of the necrosis found 24 hr after the intraperitoneal administration of $CCl_4$. The present study shows the liver protective action of the Welsh onion against experimentally induced liver damage in rats. This suggests that the Welsh onion may be used as an effective hepatoprotective agent.

본 실험에서는 랫드에 사염화탄소 중독을 유발하여 국내산 대파의 약물성 간장 장애에 대한 보호 효과를 알아보고자 하였다. 모든 실험동물에 대하여 복강으로 사염화탄소를 주입하였고 여름대파와 겨울대파를 그룹별로 $2\%,\;4\%,\;10\%$ (v/v)을 급여하고 약물대조 효과를 알아보기 위하여 마늘 $4\%$ 투여군을 두었다. 각 그룹에 대한 성장률과 증체율에 있어서는 대조군과 대파 처리군에서 유의할 만한 차이가 인정되지 않았다. 혈청 내 총단백질과 알부민 수치는 대조군과 처리군에서 유의할 만한 차이를 보이 지 않았다. 혈청 내 총지질의 양에서는 사염화탄소만 처리한 랫드에 비하여 대파를 급여하고 사염화탄소를 처리한 모든 군에서 감소하는 경향을 보였다(p<0.05). 여름대파 투여군에 비하여 겨울대파 처리군이 비교적 유의적으로 낮게 나타났다. 혈청 GOT와 GPT 활성도의 변화에서는 여름대파에 비하여 겨울대파가 유의적으로 낮게 나타나 대파의 급여가 간독성의 방어에 유의 할만한 효과가 있는 것으로 나타났다. 혈청내 ALP 활성도 역시 대파 투여군과 마늘 투여군이 사염화탄소 단독 투여군에 비해 유의성은 없지만 다소간 낮게 나타났다. 사염화탄소 투여한 랫드의 간장 병변은 간장의 섬유화, 공포변성 및 괴사 소견이 나타났으나, 대파 투여군에서 사염화탄소 단독투여 랫드군에 비하여 병변의 억제효과가 나타났다. 이상의 결과 여름대파와 겨울대파는 생체내에서 사염화탄소의 중독시의 간장손상에 대하여 보호 효과를 보이는 것으로 나타났다.

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