Research in Plant Disease (식물병연구)

The Korean Society of Plant Pathology (한국식물병리학회)
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The Importance of Host Factors for the Replication of Plant RNA Viruses

식물 바이러스 증식에 관여하는 기주 요인의 중요성

  • Park Mi-Ri (School of Agricultural Biotechnology and Center for Plant Molecular Genetics and Breeding Research, Seoul National University) ;
  • Kim Kook-Hyung (School of Agricultural Biotechnology and Center for Plant Molecular Genetics and Breeding Research, Seoul National University)
  • 박미리 (서울대학교 농생명공학부 식물분자유전육종연구센터) ;
  • 김국형 (서울대학교 농생명공학부 식물분자유전육종연구센터)
  • Published : 2005.12.01
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Abstract

All viruses have few genes relative to their hosts. Viruses, thus, utilize many host factors for efficient viral replication in host cell. Virus-host interactions are crucial determinations of host range, replication, and pathology. Host factors participate in most steps of positive-strand RNA virus infection, including entry, viral gene expression, virion assembly, and release. Recent data show that host factors play important roles in assembling the viral RNA replication complex, selecting and recruiting viral RNA replication templates, activating the viral complex for RNA synthesis, and the other steps. These virus-host interactions may contribute to the host specificity and/or pathology. Positive-strand RNA viruses encompass over two-thirds of all virus genera and include numerous pathogens. This review focuses on the importance of host factors involved in positive strand plant RNA virus genome replication.

기주 식물체 내에서 식물바이러스의 증식과 이동 여부는 바이러스 게놈과 기주 간의 상호작용에 의해 결정된다. 바이러스는 기주 내에서 바이러스가 증식하고 이동하기 위해서는 기주의 요소들을 이용해야 하며, 이러한 기주 요소들은 바이러스의 기주내 침입(entry),바이러스 유전자의 발현, 그리고 바이러스 입자형성(virion assembly) 등 모든 과정에서 직접적으로 관여를 하거나, 또는 기주 단백질 발현과 저항성을 조절하여 바이러스 증식에 간접적으로 관여를 한다. 기주 요소들과 상호작용을 통해서 바이러스 증식에 관여함으로써, 기주 특이성 및 바이러스의 병 발생에 관여를 할 것으로 보고 있다.

Keywords

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