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The Pharmaceutical Society of Korea (대한약학회)
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Iridoid Glycosides Isolated from Oldenlandia diffusa Inhibit LDL-Oxidation

  • Kim Dong-Hyun (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Lee Hyo-Jung (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Oh Young-Jun (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Kim Min-Jung (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim Sung-Hoon (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Jeong Tae-Sook (Korea Research Institute of Bioscience and Biotechnology) ;
  • Baek Nam-In (Graduate School of Biotechnology, Kyung Hee University)
  • Published : 2005.10.01
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Abstract

An iridoid glycoside, oldenlandoside III (5) was isolated from the n-butanol fraction of methanol extracts of the aerial parts of Oldenlandia diffusa Roxb. along with six others previously characterized iridoid glycosides; geniposidic acid (1), scandoside (2), feretoside (3), 10-O-ben-zoylscandoside methyl ester (4), asperulosidic acid (6) and deacetylasperulosidic acid (7). Compounds 1, 2, and 7 inhibited LDL-oxidation, and showed $63.3{\pm}2.0,\;62.2{\pm}1.6,\;and\;63.8{\pm}1.5\%$ inhibition, respectively, at a concentration of 20 ${\mu}g/mL$.

Keywords

References

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