YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Inhibitory Effect of Ferulic Acid and Related Phenolic Compounds against Cancer Cell Lines

Ferulic Acid와 관련 페놀화합물의 암세포주에 대한 독성억제효과

  • Han, Du Seok (Department of Oral Anatomy, School of Dentistry and Department of Herbal Resources) ;
  • Chun, Joo Won (Department of Oral Anatomy, School of Dentistry and Department of Herbal Resources) ;
  • Jeon, Sung Woo (Department of Oral Anatomy, School of Dentistry and Department of Herbal Resources) ;
  • Ba다, Seung Hwa (Department of Oral Anatomy, School of Dentistry and Department of Herbal Resources)
  • 한두석 (원광대학교 치과대학 구강해부학교실) ;
  • 전주원 (원광대학교 치과대학 구강해부학교실) ;
  • 전성우 (원광대학교 치과대학 구강해부학교실) ;
  • 백승화 (원광대학교 치과대학 구강해부학교실)
  • Published : 2005.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

The inhibitory effect of ferulic acid and related phenolic compounds on the growth of normal cell lines and can­cer cell line was evaluated by the MTT and XTT methods. Ferulic acid decreased the cell viability of human skin melanoma cells by the MTT method and the cell adhesion activity of human oral epithelioid carcinoma cells by the XTT method. These results suggest that ferulic acid has a potential anticancer activity.

Keywords

References

  1. Cao, Y., Lou, C., Fang, Y. and Ye, J. : Determination of active ingredients of Rhododendron dauricum L. by capillary electrophoresis with electrochemical detection. J Chromatogr. 943, 153 (2002) https://doi.org/10.1016/S0021-9673(01)01434-0
  2. Xu, L., Liu, J., Min, D., Wang, S., Zhang, Z., Guo, D. and Zheng, K. : Chemical constituent. Zhongguo Zhong Yao Za Zhi. 23, 293 (1998)
  3. Kong, L. D., Abliz, Z., Zhou, C. X., Li, L. J., Cheng, C. H. and Tan, R. X. : Glycosides and xanthine oxidase inhibitors from Conyza bonariensis. Phytochemistry 58, 645 (2001) https://doi.org/10.1016/S0031-9422(01)00160-1
  4. De Heredia, J. B., Torregrosa, J., Dominguez, J. R. and Peres, J. A. : Kinetic model for phenolic compound oxidation by Fenton's reagent. Chemosphere. 45, 85 (2001) https://doi.org/10.1016/S0045-6535(01)00074-1
  5. Andrade, P. B., Oliveira, B. M., Seabra, R. M., Ferreira, M. A., Ferreres, F. and Garcia-Viguera, C. : Analysis of phenolic compounds in Spanish Albrarino and Portuguese Alvarinho and Loureiro wines by capillary zone electrophoresis and high-performance liquid chromatography. Electrophoresis 22, 1568 (2001) https://doi.org/10.1002/1522-2683(200105)22:8<1568::AID-ELPS1568>3.0.CO;2-K
  6. Dawidar, A. M., Ezmiriy, S. T., Abdel-Mogib, M., el-Dessouki, Y. and Angawi, R. F. : New stilbene carboxylic acid from Convolvulus hystrix. Pharmazie. 55, 848 (2000)
  7. Heilmann, J., Calis, I., Kirmizibekmez, H., Schuhly, w., Harput, S. and Sticher, O. : Radical scavenger activity of phenylethanoid glycosides in FMLP stimulated human polymorphonuclear leukocytes: structure-activity relationships. Planta Med. 66, 746 (2000) https://doi.org/10.1055/s-2000-9566
  8. Hirota, A., Taki, S., Kawaii, S., Yano, M. and Abe, N.: 1,1-Diphenyl-2-picrylhy-drazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines. Biosci Biotechnol Biochem. 64, 1038 (2000) https://doi.org/10.1271/bbb.64.1038
  9. Li, Z., Inou, M., Nose, M., Kojima, K., Sakaguchi, N., Isuzugawa, K., Takeda, T. and Ogihara, Y. : Metabolic fate of gallic acid orally administered to rats. Biol. Pharm. Bull. 22, 326 (1999) https://doi.org/10.1248/bpb.22.326
  10. Sakaguchi, N., Inoue, M. and Ogihara, Y. : Reactive oxygen species and intracellular $Ca^{2+}$, common signals for apotosis induced by gallic acid. Biochem. Pharmacol. 55, 1973 (1998) https://doi.org/10.1016/S0006-2952(98)00041-0
  11. Mosmann, T. : Rapid colorimetric assays for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55 (1983) https://doi.org/10.1016/0022-1759(83)90303-4
  12. 채영암, 구자옥, 서학수, 이영만 : 기초생물학, 향문사, p. 179 (1991)
  13. Inoue, M., Suzuki, R., Sakaguchi, N., Li, Z., Takeda, T., Ogihara, Y., Jiang, B. Y. and Chen, Y. : Selective induction of cell death in cancer cells by gallic acid. Biol. Pharm. Bull. 18, 1526 (1995) https://doi.org/10.1248/bpb.18.1526