Journal of Microbiology and Biotechnology

  • 제15권5호
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  • Pages.971-976
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  • 2005
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Relationship Between Fractal Dimension and Morphological Features of Cephalosporium acremonium M25 in a 30-1 Bioreactor Culture

  • Lim Jung-Soo (Department of Chemical and Biological Engineering, Korea University) ;
  • Kim Jung-Mo (Department of Chemical and Biological Engineering, Korea University) ;
  • Kim Jong-Chae (Department of Chemical and Biological Engineering, Korea University) ;
  • Kim Chang-Ho (Bio M&D Co.) ;
  • Yang Dae-Ryook (Department of Chemical and Biological Engineering, Korea University) ;
  • Chang Hyo-Ihl (Graduate School of Biotechnology, Korea University) ;
  • Kim Seung-Wook (Department of Chemical and Biological Engineering, Korea University)
  • 발행 : 2005.10.01
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초록

In a 30-1 bioreactor culture, whole differentiation occurred from 48 h, and then proceeded rapidly. As swollen hyphal fragments and arthrospores increased, cephalosporin C (CPC) production increased exponentially to $1.85\;g/1^{-1}$ at 72 h. To explain the morphological changes of Cephalosporium acremonium M25 more quantitatively, specific differentiation rates and fractal analysis were employed. Specific differentiation rates of morphological factors varied greatly during the period of culture time from 48 h to 72 h, when CPC production increased significantly. Changes of fractal dimensions showed a pattern similar to that of the specific rate of arthrospores. Furthermore, it was inversely related to the specific rate of tips. Overall, it was suggested that the fractal dimension had potential for a new morphological parameter of fungal morphology, showing complex differentiation patterns.

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