Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

THE EXPERIMENTAL STUDY FOR INFLUENCE OF FIBRIN GLUE DURING HEALING PHASE AFTER MAKING ARTIFICIAL BONE DEFECT

백서 두개골 결손부의 골재생에 fibrin glue가 미치는 영향에 관한 실험적 연구

  • Rim, Jae-Suk (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Jang, Hyon-Seok (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Eune, Jung-Ju (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Lee, Eui-Seok (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Park, Eun-Yong (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Suh, Je-Duck (Department of Oral and Maxillofacial Surgery, Seoul National University, Boramae Hospital)
  • 임재석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 장현석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 윤정주 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 이의석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 박은용 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 서제덕 (서울대학교 보라매병원 치과 구강악안면외과)
  • Published : 2005.09.30
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Abstract

Fibrin glue is composed of fibrinogen and thrombin and used in various regions for multiple use. Basic principle is that thrombin converts fibrinogen to fibrin in the presence of $Ca^{2+}$. The structure of fibrin is loose at the beginning, but after about 5 minutes a tight structure is formed under the influence of factor VIII which changes fibrin monomer into fibrin polymer. Fibrin glue is used for tissue adhesive, suture, local hemostasis, wound healing, closure of subdural space. Fibrin adhesive has been used in oral and maxillofacial surgery for hemostasis after tooth extraction in patients with coagulation disorders, skin graft fixation, reattachment of periodontal flaps, in combination with autogenous bone chips to fill the bony cavities following cyst removal, and for securing the hydroxyapatite granules for maxillary alveolar ridge augmentation. This study was designed for researching influence of fibrin glue during healing phase after making artificial bone defect.

Keywords

References

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