Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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EXPRESSION OF TGF-$\beta$ AND IGF-I DURING OSSEOINTEGRATION OF TITANIUM IMPLANT

타이타늄 임프란트 골유착시 TGF-$\beta$와 IGF-I의 발현

  • Lee, In-Woong (Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dental Science, The Catholic University of Korea) ;
  • Song, Hyun-Chul (Div. of Oral and Maxillofacial Surgery, Dept. of Dentistry, St. Vincent's Hospital, The Catholic University of Korea) ;
  • Jee, Yu-Jin (Div. of Oral and Maxillofacial Surgery, Dept. of Dentistry, St. Vincent's Hospital, The Catholic University of Korea)
  • 이인웅 (가톨릭대학교 임상치과학대학원 구강악안면외과학과) ;
  • 송현철 (가톨릭대학교 성빈센트병원 치과 구강악안면외과) ;
  • 지유진 (가톨릭대학교 성빈센트병원 치과 구강악안면외과)
  • Published : 2005.03.31
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Abstract

Many of the molecular and genotypic events taking place at the osteoblast cell level during bone-implant integration are still largely unknown. The objective of this study was to examine expression patterns of TGF-$\beta$ and IGF-I related genes during bone-implant integration. Titanium implants with machined surface were placed into 8 rabbit tibias. At 3rd, 7th, 14th, 28th day after implantation, the expression pattern of TGF-$\beta$ and IGF-I genes in bone with or without implant was examined using reverse transcriptase-polymerase chain reaction (RT-PCR). At the same time, histomorphometric analysis was evaluated, respectively. The bone-to-implant contacts (BIC) of experimental groups were 5.2%, 6.2%, 6.6%, 24.6% at 3rd, 7th, 14th, 28th day. This indicated that newly formed bone increased at the implant surface in bone marrow space after implantation. The expressions of TGF-$\beta$ and IGF-I were higher in implantation groups than untreated control groups during all experimental days. The increased expression of TGF-$\beta$ and IGF-I genes may be associated with the increased bone-to-implant contact. This result provided the evidence for existing biologic differences in tissue response after implantation and helped us to understand molecular biologic processes in tissue-implant integration.

Keywords

References

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