Abstract
The purpose of this study was to assess intra-individual variations of clinicochemical parameters and calculate critical differences in healthy dogs during long-term periods. To calculate the critical difference of clinicochemical parameters, blood samples from 20 apparently clinically healthy dogs were collected once weekly for eight consecutive weeks. The critical difference was calculated as 9.01 mg/dl for urea, 0.52 mg/dl for creatinine, 0.99 g/dl for total protein, 0.39 g/dl for albumin, and 20.64 mg/dl for glucose. If two consecutive results differ by less than the critical difference value, it can be concluded that the difference is probably due to physiological variation. However, when the difference is greater than the critical value, other factors, either related to progression of the disease or the presence of concurrent disease, are more likely to be involved.
이 연구의 목적은 BUN 및 혈청 creatining, total protein, albumin과 glucose의 장기간에 걸친 개체 내 변이를 산정하여, 각각의 critical difference를 구성하는 것이다. 임상적으로 건강한 20마리의 개에서 일주일에 한번씩 총 8주간 채혈하여, 장기간에 걸친 개체 내 변이를 구하고, critical difference를 산출하였다. BUN은 9.01 mg/dl, 혈청 creatining은 0.52 mg/dl, total protein은 0.99 g/dl, albumin은 0.39 g/dl, glucose는 20.64 mg/dl로 critical difference가 산출되었다. 동일한 개에서 연속적으로 측정된 검사항목 치가 critical value보다 차이가 적으면, 이 차이는 생리적인 변화에 기인한다고 할 수 있으며, critical value보다 차이가 크면, 다른 요인, 즉 질병의 진행이나 다른 동반된 질병의 존재를 의미한다고 할 수 있다.
