한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제33권3호
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  • Pages.159-168
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  • 2005
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  • 1598-642X(pISSN)
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  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

신생아 장내 미생물의 형성과 이의 분석을 위한 분자 생태학적 기술

Development of Intestinal Microorganisms and Molecular Ecological Methods for Analysis of Intestinal Ecosystem in the Neonate

  • 박자령 (한국생명공학연구원 생물자원센터, 연세대학교 생명공학과) ;
  • 배진우 (한국생명공학연구원 생물자원센터) ;
  • 이성근 (충북대학교 미생물학과) ;
  • 남영도 (한국생명공학연구원 생물자원센터) ;
  • 오종원 (연세대학교 생명공학과) ;
  • 박용하 (한국생명공학연구원 생물자원센터)
  • Park Ja Ryeong (Biological Resources Center, Korea Research Institute of Bioscience and Biotechology(KRIBB), Department of Biotechnology, Yonsei University) ;
  • Bae Jin-Woo (Biological Resources Center, Korea Research Institute of Bioscience and Biotechology(KRIBB)) ;
  • Rhee Sung-Keun (Department of Microbiology, Chungbuk National University) ;
  • Nam Young-Do (Biological Resources Center, Korea Research Institute of Bioscience and Biotechology(KRIBB)) ;
  • Oh Jong-Won (Department of Biotechnology, Yonsei University) ;
  • Park Yong-Ha (Biological Resources Center, Korea Research Institute of Bioscience and Biotechology(KRIBB))
  • 발행 : 2005.09.01
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초록

인간의 장(腸)은 태어날 때만 해도 무균 상태이지만 태어나면서 산모나 주위 환경에 의해 미생물이 형성되기 시작한다. 미생물은 숙주 안에서 면역, 영양학적, 생리학적, 보호과정 등의 특징을 유발시키며, 밀접한 상호작용을 한다[6,24, 35]. 많은 연구를 통해 장내 미생물이 우리에게 주는 이로운 점들이 밝혀 지긴 했지만, 우리가 목표로 하는 장내 미생물이 숙주의 장내, 건강 상태를 조절하는 메커니즘은 아직 뚜렷하게 밝혀 지지 않고 있다. 즉, 숙주(인간)의 건강의 상태를 결정지어 주는 장내미생물 biomarker의 확립이 아직 불분명한 상태이다. 장내미생물의 방대한 다양성으로 인하여, 이를 연구하기 위한 분자 생태학 기술의 올바른 접목과 더 나은 방향으로의 기술 발전이 필요하다. 앞으로 더 나은 기술 개발을 통해, 신생아 장내의 초기에 형성되는 미생물을 검출하고, 여러 외부 요인에 따라 어떻게 연속되어 가면서 어떠한 역할을 하는지를 밝힐 수 있다면, 질병 치료뿐 아니라 예방도 가능해 질 것이다.

Up to date, a number of review papers were reported on intestinal microorganisms that influence the health and disease of human being and diet that directly influence the establishment of intestinal microbial populations. Importance of studying intestinal microorganisms in the neonate arises from the easy approach to studying initial acquisition and settlement of intestinal microorganisms. Despite of the importance, few studies of neonatal intestinal microorganisms have been carried out and there is no paper focusing the factors to influence the development of intestinal microorganisms and molecular ecological methods for the analysis of intestinal ecosystem in the neonate. In this review, we summarized the status of our current knowledge of basic initial acquisition and settlement of intestinal microorganisms. And recent development of molecular ecological methods in studying the intestinal microbiology was also discussed.

키워드

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