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The Pharmaceutical Society of Korea (대한약학회)
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An Efficient Synthesis of Risperidone via Stille Reaction: Antipsychotic, $5-HT_2$, and $Dopamine-D_2-Antagonist$

  • Published : 2005.09.01
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Abstract

Risperidone has been reported to have neuroleptic activity. In this study, risperidone was synthesized using a new method involving a stille reaction, in which 2-methyl-3-vinyl-6,7,8,9-tet­rahydropyrido[1 ,2-a]pyrimidin-4-one was synthesized (5). The chemical synthesis process was found to be simple and produced risperidone in a high yield. In addition, can be easily scaled up for large scale synthesis.

Keywords

References

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