Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Structure and Antiinflammatory Activity Relationships of Wogonin Derivatives

  • Jang, Jin-Hee (College of Pharmacy, Kangwon National University) ;
  • Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University) ;
  • Park, Hae-Il (College of Pharmacy, Kangwon National University)
  • Published : 2005.08.01
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Abstract

A number of wogonin derivatives have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of $PGE_2$ production. Wogonin derivatives modified at the B ring of wogonin were obtained from 2,4-Dihydroxy-3,6-dimethoxyacetophenone (1) via several steps. Most wogonin derivatives exhibited much reduced inhibitory activities against COX-2 catalyzed $PGE_2$ production compared to that of wogonin. Alkylation of 5,7-phenol groups and substitution at the B ring of wogonin generally caused reduction of inhibitory activity.

Keywords

References

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