Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Antimalarial activity of thiophenyl- and benzenesul-fonyl-dihydroartemisinin

  • LEE Seokjoon (Department of Basic Science and Yonsei University) ;
  • OH Sangtae (Department of Chemistry, Yonsei University) ;
  • PARK Gab-Man (Department of Parasitology, Kwandong University College of Medicine) ;
  • KIM Tong-Soo (Department of Medical Zoology, National Institute of Health) ;
  • RYU Jae-Sook (Department of Parasitology, Hanyang University College of Medicine) ;
  • CHOI Han-Kyu (Department of Parasitology, Hanyang University College of Medicine)
  • Published : 2005.09.01
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Abstract

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10$\beta$-benzenesulfonyl-dihy-droartemisinin showed stronger antimalarial activity than artemisinin.

Keywords

References

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