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Antimalarial activity of thiophenyl- and benzenesul-fonyl-dihydroartemisinin  

LEE Seokjoon (Department of Basic Science and Yonsei University)
OH Sangtae (Department of Chemistry, Yonsei University)
PARK Gab-Man (Department of Parasitology, Kwandong University College of Medicine)
KIM Tong-Soo (Department of Medical Zoology, National Institute of Health)
RYU Jae-Sook (Department of Parasitology, Hanyang University College of Medicine)
CHOI Han-Kyu (Department of Parasitology, Hanyang University College of Medicine)
Publication Information
Parasites, Hosts and Diseases / v.43, no.3, 2005 , pp. 123-126 More about this Journal
Abstract
Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10$\beta$-benzenesulfonyl-dihy-droartemisinin showed stronger antimalarial activity than artemisinin.
Keywords
Plasmodium falciparum; antimalarial activity; artemisinin; dihydroartemisinin; synthesis; natural product;
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