Journal of the Korean Society of Food Culture (한국식생활문화학회지)

Korean Society of Food Culture (한국식생활문화학회)
권호 표지

Effect of Onion Flesh or Peel Feeding on Antioxidative Capacity in 16-Month-old Rats Fed High Iron Diet

양파 육질 및 껍질의 섭취가 고철분식이를 공급한 노령흰쥐의 항산화능에 미치는 영향

  • Park, Ju-Yeon (Department of Food & Nutritional Sciences, Ewha Womans University) ;
  • Kim, Mi-Kyung (Department of Food & Nutritional Sciences, Ewha Womans University)
  • 박주연 (이화여자대학교 식품영양학과) ;
  • 김미경 (이화여자대학교 식품영양학과)
  • Published : 2005.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Recently, epidemiological evidence has raised concerns that moderate elevation in body iron stores may increase oxidative stress and the risk of cardiovascular disease and cancer. Onion flesh or peel contains antioxidant such as flavonoids and alk(en)ylcysteine sulphoxides. This study was conducted to examine the effect of onion flesh or peel feeding on antioxidative capacity in aged rats supplemented with high dietary iron. Thirty-two Sprague-Dawley male 16-month-old rats weighing $618{\pm}6g$ were acclimated for 10 days with medium-iron diet (35ppm in diet), and blocked into 4 groups according to their body weights and raised for 3 months on either control diets (adequate iron-35ppm or high iron-350ppm) or experimental diets containing onion flesh/peel (5% w/w in diet) with high iron (350ppm). Rats fed high iron-onion peel diet had significantly high quercetin and isorhamnetin levels in plasma whereas rats fed high iron-onion flesh diet did not show. Plasma TBARS level was lowered by onion flesh or peel diet with high iron supplementation. However, there was no significant difference in cellular DNA damage in brain and kidney tissue among all experimental groups. We concluded that high iron diet (10 times higher than requirement) tend to increase oxidative stress and it is plausible that onion flesh or peel feeding enhances antioxidative capacity in the elderly even with iron supplementation.

Keywords

References

  1. Population projection for Korea 2000-2050 Korean national statistical office
  2. Aging Kim, S.H.;Kim, H.Y.
  3. Am Geriatr Soc v.44 Systemic oxidative stress and its relationship with age and illness Mezzetti, A.;Lapenna, D.;Romano, F.;Costantini, F.;Pierdomenico, S.D.;De Cesare, D.;Cuccurillo, F.;Riario-Sforza, G.;Zulaini, G.;Fellin, R.;Sabin, A.M. https://doi.org/10.1111/j.1532-5415.1996.tb03741.x
  4. Iron and human disease Lauffer, R.B.
  5. Coordination Chemistry Reviews v.144 Molecular aspects of iron uptake and storage in ferritin Proula-Curry, P.M.;Chasteen, N.D. https://doi.org/10.1016/0010-8545(95)01148-I
  6. Measurement of iron status. In Iron British Nutrition Foundation
  7. Am J Clin Nutr v.76 no.6 Dietary iron intakes and elevated iron stores in the elderly: is it time to abandon the set-point hypothesis of regulation of iron absorption? Beard, J.
  8. Korean J Nutr v.30 Patterns of Vitamin - Mineral Supplement Usage by the Elderly in Korea Song, B.C.;Kim, M.K.
  9. Am J Clin Nutr v.76 no.6 Dietary factors associated with the risk of high iron stores in the elderly Framingham Heart Study cohort Fleming, D.J.;Tucker, K.L.;Jacques, P.F.;Dallal, G.E.;Wilson, P.W.;Wood, R.J.
  10. Circulation v.86 no.3 Stored iron and ischemic heart disease. Empirical support for a new paradigm Sullivan, J.L. https://doi.org/10.1161/01.CIR.86.3.1036
  11. Arterioscler Thromb v.14 A serum ferritin, sex hormones, and cardiovascular risk factors in healthy women Berge, L.N.;Bonaa, K.H.;Nordoy, A. https://doi.org/10.1161/01.ATV.14.6.857
  12. Int J Cancer v.56 Moderate elevation of body iron level and increased risk of cancer occurrence and death Stevens, R.G.;Grubard, B.I.;Micozzi, M.S.;Neriishi, K.;Blumberg, B.S. https://doi.org/10.1002/ijc.2910560312
  13. J Natl Cancer Inst v.86 Body iron stores and risk of colonic neoplasia Nelson, R.L.;Davis, F.G.;Sutter, E.;Shbin, L.H.;Kitendall, J.W.;Bowen, P. https://doi.org/10.1093/jnci/86.6.455
  14. Semin Peprod Endocrinol v.16 Oxygen radicals, antioxidants, and lipid peroxidation Sutanam, N.;Ramachandran, S.;Parthasarathy, S. https://doi.org/10.1055/s-2007-1016287
  15. J Nutr Biochem v.7 Status of lipids, lipid peroxidation, and antioxidant systems with vitamin C supplementation during aging in rats Jayachandran, M.;Jayanthi, B.;Sundaravadivel, B.;Panneerselvan, C. https://doi.org/10.1016/0955-2863(96)00027-7
  16. Am J Clin Nutr v.76 Iron stores and cadiovascular disease risk factors in women of reproductive age in United States Ramakishnan, U.;Kuklina, E.;Stein, A.D.
  17. Am J Clin Nutr v.76 Iron indexes and total antioxidant status in response to soy protein intake in perimenpopausal women Swain, J.H.;Alekel, D.L.;Dent, S.B.;Peterson, C.T.;Reddy, M.B.
  18. Nutr Cancer v.20 Intake of potentially anticarcinogenic flavonoid and their determinants in adults in the Netherlands Hertog, M.G.L.;Hollman, P.C.H.;Katan, M.B.;Kromout, D. https://doi.org/10.1080/01635589309514267
  19. Arch Int Med v.155 Flavonoid intake and long term risk of coronary heart disease in the 7 countries study Hertog, M.G.L. https://doi.org/10.1001/archinte.1995.00430110096010
  20. Abstract of 2001's Spring Associated Workshop of Korean Nutrition Society Suevey of flavonoids and carotenoids intake of Korean adults by using frequency survey of food intake Kim, Y.A.;Park, Y.K.;Park, E.J.;Kang, M.H.
  21. Phytochemistry v.47 Flavonoids from red onion (Allium cepa) Fossen, T.;Pedersen, A.T.;Andersen, O.M. https://doi.org/10.1016/S0031-9422(97)00423-8
  22. Korean Journal of Food Science and Technology v.29 Antioxidant activity of solvent extract from onion skin Ra, K.S.;Suh, H.J.;Chung, S.H.;Son, J.Y.
  23. Korean J Soc Food Sci v.14 Antioxidant activity of onion skin extract Son, J.Y.;Son, H.S.;Cho, W.D.
  24. J Nutr v.123 AIN-93 purified diets for laboratory rodents: Final report of the American Institute Nutrition Ad Hoc wrighting Committee on the reformulation of the AIN-79A rodent diet Reeves, P.G.;Nielsen, F.H.;Fahey, G.C.
  25. Nutrient requirements of laboratory animals Nutrition Research Council
  26. J Neurochem v.13 no.8 Regional studies of catecholamines in the rat brain. I. The composition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions in brain Glowinski, J.;Iversen, L.L. https://doi.org/10.1111/j.1471-4159.1966.tb09873.x
  27. FASEB Letters v.426 Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties Manach, C.;Morand, C.;Crespy, V.;Demigne, C.;Texier, O.;Regerat, F.;Remesy, C. https://doi.org/10.1016/S0014-5793(98)00367-6
  28. Free radical Biology & Medicine v.27 Comparison of the bioavailability of quercetin and cathechin in rats Manach, C.;Texier, O.;Moran, C.;Crespy, V.;Regerat, F.;Demigue, C.;Remesy, C. https://doi.org/10.1016/S0891-5849(99)00159-8
  29. J Nutr v.115 Effect of dietary polyunsaturated/saturated fatty acid ratio and dietary vitamin E on lipid metabolism in the rat Buckingham, K.W.
  30. J Neuroscience Methods v.68 A reliable and sensitive enzyme immunoassay method for measuring 8-isoprostaglandin F2a: a marker for lipid peroxidation after experimental brain injury Hoffman, S.W.;Robin, L.R.;Stein, D.G. https://doi.org/10.1016/0165-0270(96)00014-3
  31. Effects of onion flesh or peel feeding on antioxidative capacity and iron metabolism in 16-month-old rats oxidatively stressed with dietary iron Park, J.
  32. Biosci Biotechnol Biochem v.67 Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats Azuma, K.;Ippoushi, K.;Ito, H.;Horie, H.;Terao, J. https://doi.org/10.1271/bbb.67.2548
  33. American J Physiol Plasma metabolites of quercetin and their antioxidant properties Morand, C.;Crespy, V.;Manach, C.;Besson, C.;Denigne, C.;Remesy
  34. Phytother Res v.16 Onions-A global benefit to health Griffiths, G.;Truemann, L.;Crowther, T.;Thomans, B.;Smith, B. https://doi.org/10.1002/ptr.1222
  35. Biochem Pharmacol v.38 Chelating and free radical scavenging mechanism of inhibitory action of rutin and quercetin in lipid peroxidation Afanas'ev, I.B.;Dorozhko, A.L.;Brodskii, A.V.;Kostyuk, V.A.;Potapovitch, A.I. https://doi.org/10.1016/0006-2952(89)90410-3
  36. Br J Nutr v.81 Inhibition on non-haem iron absorption in man by polyphenolic-containing beverages Hurrell, R.F.;Reddy, M.;Cook, J.D.
  37. J Nutr v.132 High dietary iron concentrations enhances the formation of cholesterol oxidation products in the liver of adult rats fed salmon oil with mineral effects on antioxidant status Brandsch, C.;Ringseis, R.;Eder, K.
  38. Korean J Nutr v.37 Effect of onion flesh or peel feeding with different iron level on lipid metabolism, antioxidative capacity, and antithrombogenic capacity in 16-month-old rats Kim, S.K.;Kim, M.K.
  39. Brain Res v.610 Oxidative stress in duced by glutamate receptor agonists Bondy, S.C.;Lee, D.K. https://doi.org/10.1016/0006-8993(93)91405-H
  40. Renal Physiol Biochem v.17 Inhibition of high-affinity glutamate transport in neuronal and glial cells by arachidonic acid and oxygen-free radicals: Molecular mechanisms and neuropathological relevance Le Poncin-Laffitte, M.;Martin, P.;Lespinasse, P.;Rapin, J.R.
  41. Korean J Nutr v.34 no.5 Effect of dry powders, ethanol extracts and juices of radish and onion on lipid metabolism and antioxidative capacity in rats An, S.J.;Kim, M.K.
  42. Experimental Gerontology v.36 Levels of 8-hydroxy-2'-deoxyguanosine in cellular DNA from 12 tissues of young and old Sprague-Dawley rats Schmerold, I.;Niedermuller, H. https://doi.org/10.1016/S0531-5565(01)00103-6
  43. Glutathione in the brain: disorders of glutathione metabolism;The molecular and genetic basis of neurological disease Cooper, A.J.L.;Rosenberg, R.N.(ed.);Prusiner, S.B.(ed.);DiMauro, S.(ed.);Barch, R.L.(ed.);Klunk, L.M.(ed.)
  44. Prog Lipid Res v.29 The role of alterations in membrane lipid composition in enabling physiological adaptation of organisms to their physical environment Hazel, J.R.;Williams, E.E. https://doi.org/10.1016/0163-7827(90)90002-3
  45. Neurological Aging v.16 Are reactive oxygen species involved in Alzheimer's disease? Benzi, G.;Moretti, A. https://doi.org/10.1016/0197-4580(95)00066-N
  46. Annu Rev Biochem v.63 Repair of oxidative damage to DNA: Enzymology and Biology Dample, B.;Harrision, L. https://doi.org/10.1146/annurev.bi.63.070194.004411
  47. Neuroscience v.79 Regional distribution of iron, transferrrin, ferritin, and oxidatively-modified proteins in young and aged Fisher 344 rat brains Focht, S.J.;Snyder, B.S.;Beard, J.L.;Van Gelder, W.;Williams, L.R.;Connor, J.R. https://doi.org/10.1016/S0306-4522(96)00607-0
  48. Nutritional and health aspects;Food antioxidants Deshpande, S.S.;Deshpande, U.S.;Salunke, D.K.;Madhavi, D.L.(ed.);Deshpande, S.S.(ed.);Salunkhe, D.K.(ed.)
  49. Am J Clin Nutr v.67 Effects of flavonoids and vitamin C on oxodative DNA damage to haman lympocytes Noroozi, M.;Angerson, W.J.;Lean, M.E.
  50. J Nutr v.130 Variations in dietary iron alter brain iron metabolism in developing rats Pinero, D.J.;Li, N.Q.;Connor, J.R.;Beard, J.L.