Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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A STUDY ON THE BONE FORMATION OF GRAFT MATERIAL CONTAINING DEMINERALIZED BONE MATRIX WITH A SIMULTANEOUS INSTALLATION OF IMPLANT

임프란트 식립시 이식된 탈회골기질을 함유한 이식재의 골형성에 대한 연구

  • Kim, Yeo-Gab (Dept. of Oral and Maxillofacial Surgery, Dental College, Kyung-Hee University) ;
  • Yoon, Byung-Wook (Dept. of Oral and Maxillofacial Surgery, Dental College, Kyung-Hee University) ;
  • Ryu, Dong-Mok (Dept. of Oral and Maxillofacial Surgery, Dental College, Kyung-Hee University) ;
  • Lee, Baek-Soo (Dept. of Oral and Maxillofacial Surgery, Dental College, Kyung-Hee University) ;
  • Oh, Jung-Hwan (Dept. of Oral and Maxillofacial Surgery, Dental College, Kyung-Hee University) ;
  • Kwon, Yong-Dae (Dept. of Oral and Maxillofacial Surgery, Dental College, Kyung-Hee University)
  • 김여갑 (경희대학교 치과대학 구강악안면외과학교실) ;
  • 윤병욱 (경희대학교 치과대학 구강악안면외과학교실) ;
  • 류동목 (경희대학교 치과대학 구강악안면외과학교실) ;
  • 이백수 (경희대학교 치과대학 구강악안면외과학교실) ;
  • 오정환 (경희대학교 치과대학 구강악안면외과학교실) ;
  • 권용대 (경희대학교 치과대학 구강악안면외과학교실)
  • Published : 2005.12.31
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Abstract

Purpose: The aim of the present study is to evaluate the effect of autogenous bone and allograft material coverd with a bioresorbable membrane on bone regeneration after a simultaneous installation of implant. Materials and methods: Twelve healthy rabbits, weighing about $3{\sim}4$ kg, were used in this experiment. Following impalnt(with 3.25 mm diameter and 8 mm length) site preparation by surgical protocol of $Oraltronics^{(R)}$, artificial bony defect, 5mm sized in height and depth, was created on femoral condyle using trephine drill(with 5 mm diameter and 5 mm length). Then implant was inserted. In the experimental group A, the bony defect was filled with autogenous particulated bone and coverd with $Lyoplant^{(R)}$ resorbable membrane. In the experimental group B, the bony defect was filled with allograft material(Orthoblast $II^{(R)}$) containing demineralized bone matrix and covered with $Lyoplant^{(R)}$. In the control group, without any graft materials, the bony defect was covered with $Lyoplant^{(R)}$. The experimental group A and B were divided into each 9 cases and control group into 3 cases. The experimental animals were sacrificed at 3, 6 and 8 weeks after surgery and block specimens were obtained. With histologic and histomorphometric analysis, we observed the histologic changes of the cells and bone formation after H-E staining and then, measured BIC and bone density with KAPPA Image $Base^{(R)}$ system. Results: As a result of this experiment, bone formation and active remodeling process were examined in all experimental groups and the control. But, the ability of bone formation of the experimental group A was somewhat better than any other groups. Especially bone to-implant contact fraction ranged from 12.7% to 43.45% in the autogenous bone group and from 9.02% to 29.83% in DBM group, at 3 and 8 weeks. But, bone density ranged from 15.67% to 23.17% in the autogenous bone group and from 25.95% to 46.06% in DBM group at 3 and 6 weeks, respectively. Although the bone density of DBM group was better than that of autogenous bone group at 3 and 6weeks, the latter was better than the former at 8 weeks, 54.3% and 45.1%, respectively. Therefore these results showed that DBM enhanced the density of newly formed bone at least initially.

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References

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